Background: Serum uric acid (SUA) levels is related with body mass index (BMI). The increased of SUA levels has been shown to be associated withobesity and hypertension. This study aims to observe the differences of the association between SUA levels, BMI, blood pressure (BP), and kidney functions in men and women. Methods: This study used “Mlati Study” database in 2007 to select a total of 417 patients with a history of prehypertension by simple random sampling using statistical software. Patients were interviewed and underwent both physical and laboratory examinations for data collection (including body weight, body height, BP, blood samples, and urine samples) in two days. High SUA levels were defined as ≥ 7 mg/dL and normal SUA levels as < 5 mg/dL.Additional analysis’s were performed using high SUA cut-off point of ≥ 6 mg/dL for women (n=450). Results: SUA levels were significantly associated with gender, where men tended to have high SUA levels compared to women (p<0.001, RR=12.39, 95%CI=6.21-24.74). Patients with overweight and obesity were significantly associated with high SUA levels, both in men and women (p<0.001, RR=2.33, 95%CI=1.34- 4.05 and p=0.016, RR=1.05, 95%CI=1.00- 1.09,respectively). Regarding kidney functions, neither uric acid excretion nor uric acid concentration had significant association with SUA levels, both in men and women.Moreover, high SUA levels were proven to be significantly related to prehypertension or hypertension, but only in women (p<0.05). Additionally, analysis for different cut-off point of high SUA levels for women also showed the same results for BMI, BP and kidney functions. Conclusion: We concluded that SUA levels in men tended to be higher than in women. Overweight and obesity were associated with high SUA level, either in men and women. Furthermore, high SUA levels were related to prehypertension and hypertension, but only in women.
Mochammad Sja'banigraduated as a Medical Doctor at the Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada (UGM), Indonesia. He became an Internist Specialist and Nephrologist in the same University. He obtained his Medical Science degree in Clinical Epidemiology and Biostatistics at the University of Newcastle, Australia. He received his doctor of Philosophy degree and Professor in UGM. He became the Head of Internal Medicine Department and Vice Head of Ethical Committee, UGM. He was also accepted as a visiting-professor to Internal Medicine, Juntendo University, Japan. He is currently as aProfessor of the Doctoral Program in the Faculty of Medicine Public Health and Nursing in UGM and Faculty of Medicine and Health Sciences in Universitas Muhammadiyah Yogyakarta, Indonesia.
Share this page on your timeline