Background: Musculoskeletal disorders (MSDs) affecting healthcare workers (HCWs) ought to never be dealt with softly. It has subsequently gotten important to incorporate ergonomics in clinical practice to prevent MSDs. The objectives of this study will be to investigate knowledge, attitudes, and practices related to ergonomics among HCWs in a large governmental healthcare facility. Methods: A cross-sectional study will be conducted in which the participants will be interviewed to complete a validated four section questionnaire (demographic data, knowledge, attitude, and practice information related to ergonomics). The questionnaire is a newly self-developed based on literaturereview and it will be pilot-tested after development. Results: This study will include 300 HCWs. Their average knowledge, attitude and scores regarding ergonomics will be calculated. The risk factors such as gender, race and educational level of knowledge, attitudes, and practices related to ergonomics among HCWs will be investigated. Conclusion: This study will assess their knowledge, attitude and practice towards ergonomics at work. It is important to apply ergonomics at work to prevent MSDs in their routine clinical work