The enduring and devastating COVID-19 pandemic has reminded the world of the importance of the health care transformation through interprofessional and inter-organizational collaboration to achieve Quadruple Aim (better health, better care, better value, and better work experience). Just like the global system-wide coordination required for vaccine development and deployment in response to the pandemic, global leadership is necessary to transform health care systems through the integration and incorporation of interprofessional education and collaborative practice (IPECP). IPECP is not just an approach or strategy, rather IPECP reflects the philosophy of teamwork and collaboration across different professions, programs, institutions, and sectors. While significant improvements in the quality of IPECP research studies have been noted, there is still much to be achieved. The current need for IPECP research is to produce significant and scientifically sound evidence determining the impact of IPECP on the improvement of health outcomes and quality care and service; lowering of health care cost and the burden on health human resources; increasing the ‘collaborative practice-readiness’ of health and social care professionals; enhancing resilience and work experience; and the eventual improvement in population health. To meet these challenges, here are the global IPECP research priorities developed by interprofessionalresearch.global (IPR.Global: the Global Network for Interprofessional Education and Collaborative Practice Research): 1. Building the science and scholarship of IPECP through the discovery and integration of innovative evidence-informed strategies. 2. Identifying and applying innovative approaches that embrace and address the inherent complexity of interprofessional endeavours in healthcare. 3. Developing evidence of impact along the continuum from education to practice To further this agenda, in this interactive speech each of the above priorities along with examples of applied IPECP theoretical frameworks and research methodologies to achieve the priorities will be discussed.