Scope: Quite disturbing is the huge public health impact of COVID-19: As at today [April 4th, 2021], the COVID-19 global burden shows over130 million cases and over 2.8 million deaths worldwide. Recent evidence shows calprotectin’s potential as a therapeutic target, stating that tasquinimod, from the Quinoline-3-Carboxamide family is capable of blocking the interaction between calprotectin and TLR4& RAGE.Hence preventing the cytokine release syndrome, that heralds the functional exhaustion in COVID-19. Early preclinical studies showed that tasquinimod inhibit tumor growth and prevent angiogenesis/cytokine storm. Phase I – III clinical studies in prostate cancer showed it has a good safety profile with good radiologic progression free survival but no effect on overall survival. Objectives: Though strategic endeavours have been amplified globally to assess new therapeutic interventions for COVID-19 treatment, the efficacy and safety of tasquinimod in COVID-19 remains to be explored. Hence the primary objective of this trial will be to evaluate the efficacy of tasquinimod in the treatment of adult patients with severe COVID-19 infections. Therefore, wehypothesize that in COVID19 adult patients, tasquinimod will reduce the severe respiratory distress associated with COVID-19 compared to placebo, over a 28-day study period. Methods: The setting is in Europe. Design –a randomized,placebo-controlled, phase II double-blinded trial.Trial lasts for 28 days from randomization, Tasquinimod capsule given as 0.5mg daily 1st fortnight, then 1mg daily 2nd fortnight. I0 outcome - assessed using six-point ordinal scale alongside eight 20 outcomes. 125 participants to be enrolled, data collection at baseline and subsequent data points, and safety reporting monitored via serological profile. Significance: This work could potentially establish tasquinimod as an effective and safe therapeutic agent for COVID-19 by reducing the severe respiratory distress, related time to recovery, time on oxygen/admission.It will also drive future research – as in larger multi-centre RCT.
Ralph Udeh is a COVID-19 researcher and a clinician with interest in the epidemiology of COVID-19, COVID-19 clinical trials, molecular virology, biostatistics, other infectious diseases and cancer. He is particularly interested in understanding the molecular underpinnings of COVID-19 and virology at large. His most recent work is focused on developing a clinical trial protocol for tasquinimod in COVID-19 [The TASQ-COVID trial]. With great enthusiasm, he looks forward to advancing his career in this field.
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Introduction: Hearing impairment in children can compromise the development of language and communication skills, academic achievements, and the negative impact of even minor alterations is recognised. Since implementation of Universal Newborn Hearing Screening, preschool and school hearing screening programmes would identify later onset or progressive hearing losses, conductive hearing loss, tinnitus and vertigo. Early identification of hearing loss is very important to provide optimal hearing conditions of school children, minimising the effects on the social, emotional and cognitive development of the individual, which are very important by the time the child starts primary school. Hearing loss can have a great impact on reading, writing, central auditory processing, and balance. Objective: Since 2002, the Coimbra Health School, Audiology BSC has developed hearing screening in the community. The objective of these screenings is to identify changes in hearing and / or in the middle ear in children between 5 and 17 years old, with a special emphasis on children aged 5-6 years. Methods: Children with parental consent were evaluated by otoscopy, tympanometry and audiometry (1, 2 and 4 KHz presented at 40 and 20 dB intensity). A small questionnaire is done to children aged 10 years and over. The results were classified as pass or refer. Every non-normal result of any category would imply referral to the child's primary health care doctor or directly to ENT specialist. Results: Over years it was found that the prevalence of audiological alterations decreases with the child's growth but at 5/6 years old it`s about 30%. This percentage is often confirmed by the observation of an ENT specialist and by audiology hospital laboratories. Conclusion: To implement and perform a preschool and school hearing screening is important and necessary but at 5-6 years (with a high predisposition to middle ear problems) hearing screening should be mandatory with the main objective of identifying and referring for treatment children who present alterations in order to reduce the consequences of the hearing impairment.
Graduated in Audiometry in 1986, completed Masters in Audiology in 2002 and PhD in Cognitive Science in 2018. Worked for 14 years in clinical set and for the last 19 years has been teaching Audiology at the Coimbra Health School, Portugal.Over the years, we have developed several activities to promote audiological health in the community through awareness-raising activities and audiological screening of different populations, but with a special emphasis on screening children of pre-school age. We participate in the development of hearing assessment and auditory training apps, aimed at improving the hearing care of the population. As a teacher we arePresident of the Scientific Committee of the Audiology Course since June 2009;Member of the Coimbra Health School Technical and Scientific Council since November 2001; and we has taught various classes for the Audiology Graduate and Masters Course,specifically:Applied investigation in Audiology; Community Audiology; and Auditory Processing.
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Firefighters are at high risk to suffer potential health effects due to their chronic exposure to a countless number of air pollutants, including polycyclic aromatic hydrocarbons (PAHs) that are released during fire occurrences. Firefighters’ exposure assessment is one of the most challenging due to the logistic reasons and thus human biomonitoring represents an accurate tool to estimate total exposure. This study assesses firefighters’ total exposure to PAHs through the determination of six urinary biomarkers of exposure (OHPAHs: 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, and 3-hydroxybenzo(a)pyrene) and two genotoxic/oxidative-effect biomarkers (basal DNA and oxidative DNA damage). Urinary concentrations of total OHPAHs were significantly increased in subjects that were recently involved in firefighting activities, being 1-hydroxynaphthalene, 1-hydroxyacenaphthene, and 2-hydroxyfluorene the compounds with the highest increments. Concentrations of urinary 1-hydroxypyrene were below the benchmark level (0.5 µmol/mol creatinine) proposed by American Conference of Governmental Industrial Hygienists; 3-hydroxybenzo(a) pyrene, metabolite of the carcinogenic benzo(a)pyrene, was not detected. Positive correlations were found between levels of total OHPAHs and the oxidative DNA damage of exposed firefighters; data forDNA damagewas inconclusive. Evidencewas raised regarding the simultaneous use of biomarkers of exposure and of effect for the surveillance of firefighters’ health and to better estimate the potential short-term health risks. Surveillance (bio) monitoring programs are needed, principally in the most severely affected countries, to better characterize short- and long-termhealth risks. Funding: This work was financially supported by the project PCIF/SSO/0090/2019 by the Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. This work received support by UIDB/50006/2020, UIDP/50006/2020, through the project PCIF/ SSO/0017/2018 by the Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. M. Oliveira was supported by the scientific contract CEEC-Individual 2017 Program Contract CEECIND/03666/2017.
Marta Oliveira graduated in Chemistry (2007), completed the Master’s in quality Control–Water/Foods (2009) and concluded her PhD on Sustainable Chemistry (2016) from the Faculty of Sciences, University of Porto and Faculty of Sciences and Technology, Nova University of Lisbon. Since 2016 she is an integrated researcher at REQUIMTE-Associated Laboratory for Green Chemistry at the School of Engineering of the Polytechnic of Porto (Portugal). Her main research interests are: i)climate change and forest fires emissions, ii)firefighters' occupational exposure, iii)human biomonitoring, iv) environmental and occupational exposure to airborne pollutants,and v)health risk assessment. She collaborates in some projects, being the principal researcher and a member of the research team in two ongoing projects dedicated to firefighters´ occupational exposure. She co-authored about 30 indexed papers (h-index:15; Scopus ID57202841330),13 book chapters, 3 indexed abstracts, 14 short papers in conference proceedings, 20 oral and more than 60 poster communications in international/national conferences.
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Introduction: Oral isotretinoin is an effective agent for the treatment of severe cystic acne. Isotretinoin is a teratogen; there is an increased risk of congenital defects in infants exposed to the drug in the uterus. The Saudi Food and Drug Authority (SFDA) has implemented a pregnancy prevention program (PPP) to protect females from those teratogenic effects. Objectives: To investigate the awareness of women, of reproductive age who were using Isotretinoin or used it previously, about isotretinoin use and the SFDA-approved PPP in Riyadh, Saudi Arabia. Methods: This cross-sectional study was conducted during the period from June to October 2019. A questionnaire was developed based on the published literature and the PPP recommendations. The study was carried out online among female patients who were on Isotretinoin therapy or have used it previously in Riyadh city. The Statistical Package for Social Sciences (SPSS for Windows, version 24) was used to analyze the study data. Results: During the study period, 483 patients participated in the study. Among them, 97.3% reported that they used the drug based on a doctor's prescription, 94.6% were aware of Isotretinoin's teratogenic effect, and 30.6% confirmed their awareness of the PPP. Amongst the participants, 9.1% (n = 44) used Isotretinoin while being married or planning to get married within a one-month period after using it. Concerning the use of two contraceptive methods according to the PPP guidelines, of the participants, 43.2% reported that they have been informed by their healthcare providers to use two contraceptive methods before starting the medication. Also 43.2% reported that they have been informed to use two contraceptive methods while using the medication, and 50% reported that they have been informed to use two contraceptive methods for one month after stopping the medication. Regardless of the information they had, participants’ actual practice, was as follow: 15.9% used two contraceptive methods before starting the medication, 15.9% used two contraceptive methods during the treatment, and 13.6% used two contraceptive methods for one month after stopping the medication. Conclusions: Although this study revealed that the vast majority of participants were aware of isotretinoin's teratogenic effect, still a considerable number of them had no idea about the PPP. This issue needs to greatly be addressed to minimize the risk of teratogenicity.
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An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that CS is mainly responsible for critical COVID-19 cases, including acute respiratory distress syndrome (ARDS). Recognizing the therapeutic potential of Spirulina blue-green algae (Arthrospira platensis), in this in vitro stimulation study, LPS-activated macrophages and monocytes were treated with aqueous extracts of Spirulina, cultivated in either natural or controlled light conditions. We report that an extract of photosynthetically controlled Spirulina (LED Spirulina), at a concentration of 0.1 µg/ mL, decreases macrophage and monocyte-induced TNF-α secretion levels by over 70% and 40%, respectively. We propose prompt in vivo studies in animal models and human subjects to determine the putative effectiveness of a natural, algae-based treatment for viral CS and ARDS, and explore the potential of a novel anti-TNF-α therapy.
Dr Dorit Avni heads the Sphingolipids and Bio-active Natural based Compounds as Immune Modulators Laboratory, at MIGAL Galilee Research Institute. She specializes in in-vitro, ex-vivo and pre-clinical models, and practices a transdisciplinary approach in her research, employing genomic, immunologic, and metabolomic techniques. Her laboratory applies bio-active metabolites as immune system regulators aiming to prevent (functional food/food supplement) as well as develops novel platforms to treat (pharma) unmet diseases, such as COVID-19, IBD, NAFLD, TNBC, and liver cancer. PhD (Tel-Aviv University, IL) focused on novel pathways for the regulation of cytokines release Post-doctoral fellowship (Massey cancer canter-VCU, USA) focused on sphingolipids in inflammation and cancer.
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International Cooperation and Development has undergone notable changes in the last recent decades and Non-Governmental Development Organizations(NGDOs) have acquired a great importance. Benin is one of the countries of sub-Saharan Africa with the most dramatic development indicators. Many NGDOs are focusing on Nikki, one of the less developedcommunities in the north-east of the country. There is evidence that quantitative prioritization methods are an optimal element to establish which health problems require the highest priority action and they also constitute an element of distributional equity. However, in countries such as Benin, their appliance is scarce, and no valid references of its use were identified in the bibliography. In this study, we modify the Hanlon method forprioritization health problemsadapting it to both, Nikki's social-sanitary characteristics and to their use by small NGDOs for the creation of health programs in the field of InternationalCooperation andDevelopment. The Modified Hanlon Method concluded after analyzing the 13 most relevant problems in the health zone that "Malaria", "Pregnancy, childbirth and perinatal diseases" and "Malnutrition" were a top priority for the development of cooperation programs by small NGDOs. In addition, an effective action carried on that 3 main health problems would have a positive impact on other relevant health problems such as "Anemias". Furthermore, the 3 highest priority health problems represented directly and indirectly two thirds of the total priority based on its impact, frequency, severityand resolution capacity. This work concludes that the use ofquantitative prioritization methodsonce adapted to the tactical and operational planning and to the targeted area are effective in order to determine the prior health problems in the scope of International Cooperation carried out by NGDOs.
Medical degree (University of Valladolid). Red cross (Valladolid association). Valladolid International Federation of Medical Students Association (Human Rights). Master in Clinic Medicine (Camilo José Cela University). Internal Medicine Residency (12 de OctubreUniversitary Hospital).
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Background: Serum uric acid (SUA) levels is related with body mass index (BMI). The increased of SUA levels has been shown to be associated withobesity and hypertension. This study aims to observe the differences of the association between SUA levels, BMI, blood pressure (BP), and kidney functions in men and women. Methods: This study used “Mlati Study” database in 2007 to select a total of 417 patients with a history of prehypertension by simple random sampling using statistical software. Patients were interviewed and underwent both physical and laboratory examinations for data collection (including body weight, body height, BP, blood samples, and urine samples) in two days. High SUA levels were defined as ≥ 7 mg/dL and normal SUA levels as < 5 mg/dL.Additional analysis’s were performed using high SUA cut-off point of ≥ 6 mg/dL for women (n=450). Results: SUA levels were significantly associated with gender, where men tended to have high SUA levels compared to women (p<0.001, RR=12.39, 95%CI=6.21-24.74). Patients with overweight and obesity were significantly associated with high SUA levels, both in men and women (p<0.001, RR=2.33, 95%CI=1.34- 4.05 and p=0.016, RR=1.05, 95%CI=1.00- 1.09,respectively). Regarding kidney functions, neither uric acid excretion nor uric acid concentration had significant association with SUA levels, both in men and women.Moreover, high SUA levels were proven to be significantly related to prehypertension or hypertension, but only in women (p<0.05). Additionally, analysis for different cut-off point of high SUA levels for women also showed the same results for BMI, BP and kidney functions. Conclusion: We concluded that SUA levels in men tended to be higher than in women. Overweight and obesity were associated with high SUA level, either in men and women. Furthermore, high SUA levels were related to prehypertension and hypertension, but only in women.
Mochammad Sja'banigraduated as a Medical Doctor at the Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada (UGM), Indonesia. He became an Internist Specialist and Nephrologist in the same University. He obtained his Medical Science degree in Clinical Epidemiology and Biostatistics at the University of Newcastle, Australia. He received his doctor of Philosophy degree and Professor in UGM. He became the Head of Internal Medicine Department and Vice Head of Ethical Committee, UGM. He was also accepted as a visiting-professor to Internal Medicine, Juntendo University, Japan. He is currently as aProfessor of the Doctoral Program in the Faculty of Medicine Public Health and Nursing in UGM and Faculty of Medicine and Health Sciences in Universitas Muhammadiyah Yogyakarta, Indonesia.
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Introduction: “Overlap syndrome (OS)” refers to patients with chronic obstructive pulmonary disease (referred to as COPD) with obstructive sleep apnea hypopnea syndrome (OSAHS). Patients with OSAHS have recurrent apnea and hypopnea during sleep, leading to hypoxemia. Patients with COPD have persistent airflow limitation and hypoxemia for a long time, which causes more severe hypoxia in OS patients. The coexistence of the two aggravates the patient’s condition, and is more likely to cause increased risk of hospitalization and mortality due to risk factors such as respiratory failure, heart failure, and arrhythmia. Objective: To study the M receptor blocker on inhalation in patients with overlap syndrome (chronic obstructive pulmonary disease and Obstructive sleep apnea syndrome) curative effect analysis. Methods: 25 patients with overlap syndrome as the experimental group, chronic obstructive pulmonary disease patients (30) as control group, patients with overlap syndrome use inhaled tiotropium powder treat 30 days, to observe the changes of pulmonary function, polysomnography, and other indicators after treatment. Results: Overlap syndrome were treated by tiotropium bromide inhalation powder, has improved the pulmonary function, the sleep apnea index and lowest nocturnal oxygen saturation after treatment. Conclusion: Tiotropium bromide has a preferable effective in treatment of overlap syndrome, COPD and OSAHS are interacting with each other.
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Introduction: “Overlap syndrome (OS)” refers to patients with chronic obstructive pulmonary disease (referred to as COPD) with obstructive sleep apnea hypopnea syndrome (OSAHS). Patients with OSAHS have recurrent apnea and hypopnea during sleep, leading to hypoxemia. Patients with COPD have persistent airflow limitation and hypoxemia for a long time, which causes more severe hypoxia in OS patients. The coexistence of the two aggravates the patient’s condition, and is more likely to cause increased risk of hospitalization and mortality due to risk factors such as respiratory failure, heart failure, and arrhythmia. Objective: To study the M receptor blocker on inhalation in patients with overlap syndrome (chronic obstructive pulmonary disease and Obstructive sleep apnea syndrome) curative effect analysis. Methods: 25 patients with overlap syndrome as the experimental group, chronic obstructive pulmonary disease patients (30) as control group, patients with overlap syndrome use inhaled tiotropium powder treat 30 days, to observe the changes of pulmonary function, polysomnography, and other indicators after treatment. Results: Overlap syndrome were treated by tiotropium bromide inhalation powder, has improved the pulmonary function, the sleep apnea index and lowest nocturnal oxygen saturation after treatment. Conclusion: Tiotropium bromide has a preferable effective in treatment of overlap syndrome, COPD and OSAHS are interacting with each other.
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Objectives: To reveal the physical symptom changes and their correlations with mental health status in deep underground miners. Methods: A total of 286 deep underground miners completed a cross-sectional questionnaire study at China Pingmei Shenma mine complex. The questionnaire includedsociodemographics, self-reported physical symptoms,underground adverse environmental factors and theSymptom Checklist-90-Revised (SCL-90-R). Five environmental parameters of one deep mine were also measured. Results: Data from266 valid questionnaires were analyzed. The three most frequent complaints about underground adverse conditions were moisture [62.03% (165/266)], dim light [45.86% (122/266)]and high temperature [42.11% (112/266)]. Fatigue [40.22% (107/266)], hearing loss [34.96% (93/266)] and tinnitus [31.58% (84/266)] were reported to be the threemost commonphysical symptoms. Insomnia was reported in 204 participants (76.69%) mainly due to the difficulty of falling asleep [42.35% (84/204)] and dreams [39.70% (81/204)]. Mean scores of SCL-90-R subscales including somatization, anxiety, phobic anxiety, psychoticism and paranoid ideation were elevated compared to Chinese norms, while there was diminished interpersonal sensitivity.Univariate analyses indicated that the threemost common physical symptoms were associated with poorer SCL90-R scores. With increasing depth below ground, air pressure, relative humidity, CO2 concentration and temperature rose, while total γ radiation dose-rate decreased. Conclusions: The physical and mental health status of deep underground miners was poorer than the general Chinese male population. Some adverse environmental factors were identified that may have influenced health status. Measures are suggested to improve the deep underground working environment.
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Presently the acceptable manner to protect oneself against the onslaught of genetically varying forms is through practicing social distancing and when coupled with the prospects of heading towards social isolation with its accompanying economic losses. Stress and anxiety is the initial reaction upon being diagnosed as positive for SARS-2 CoV RNA on PCR causing alarm in rehabilitation professionals encountering direct exposure and being vulnerableas rehabilitation of patients is necessarily carried out. Despite the electronic media blitz scientific data remains insufficient to establish definite medical and health protocols being a recent and ongoing pandemic. The current study is an attempt to review and isolate the triggerscausing fright among rehabilitation professionals thereby identifyingcredible management solutionsarising in the backdrop of Pakistan’s current pandemic of COVID-19 .In this regard literature was searched from major electronic databases including PubMed, Google, Google Scholar and Web-of-science, with keywords “Covid-19, mental health, telehealth, telemedicine, tele-rehabilitation and combination of words”. Eighty English, full text articles were analyzed out of which 36 were used for the literature review which leads to the conclusion that COVID-19 embodies fear of contracting and transmitting this disease among health professionals. This fear can be mitigated and managed by relying more on availability of tele-rehabilitation and telehealth facilities. Treatment of patients emerging from prolonged mechanical ventilations demands extensive rehabilitation to restore routine body functions. The direct and structured approach of otolaryngologists and speech language pathologists (SLP) enables appropriate and timely long term intervention and rehabilitation empowering and facilitating patientsto resume mainstream activities.
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Background: Picture Archiving and Communication System (PACS) is one of the common systems used in hospitals, which is of special importance due to its diagnostic nature. Evaluating this system from the perspective of radiologists as one of its main users can have many benefits for designing future system. In this study, the evaluation of the system was performed based on the viewpoints of radiologists. Method: This cross-sectional study was conducted using the census method of radiologists in Al-Zahra and Kashani hospitals in Isfahan. The data collection method was a standard questionnaire including 40 items with 3 options Likert scale. The analysis of the findings was performed using SPSS 21 software. Findings were presented as frequency distribution tables and the research hypothesis was tested using independent sample t-test. Results: The mean age of physicians participating in the study was 34.94 ± 6.57 years. Statistical test showed that there was a significant difference between PACS A and B in terms of potential benefits and challenges of PACS, but no significant difference was observed between the two systems in terms of systems comparison with traditional film-based system. Conclusion: Most users of both systems believe that PACS include many advantages over the traditional system and can have positive potential effects on patients care. However, issues such as slow speeds of system, system lags and disconnection, and inadequate workstations remain concerns.
I am agraduatein medical recordsat Isfahan University of Medical Sciences and now I am a PhD candidate in health information management at Kashan University of Medical Sciences.I have already published two articles on PACS evaluation in reputable journals.
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Background: Evidence from earlier studies on COVID-19 suggests that the countries led by female leaders were more successful in handling the COVID-19. Indian being patrilocal society evidence that woman’s political autonomy in autonomy in the Gram Panchayat do miracle concerning development. With this backdrop, the present paper aimed to explore the role of women’s political participation and leadership on the efficiency in combatting COVID-19 for Indian states. Methods: This predominantly empirical paper was entirely based on secondary data compiled from different sources. The empirical analysis of the paper was facilitated by the utilization of the Technical Inefficiency Effects model within the framework of Stochastic Production Frontier. The reciprocal of the death rate of COVID-19 was considered as the output variable. The health personnel and health infrastructures indicators were considered as inputs. Conversely, non-health determinants, including, women’s political leadership indicators were recognized as inefficiency effects variables. Results: The empirical result evidenced that West Bengal, a female-headed state became the second most efficient in the list followed by Karnataka. The empirical results accredited us to conclude that the efficiency of the Indian states to combat COVID-19 was highly influenced by female political participation and leadership, digitalization, urbanization, and literacy rate. Conclusion: The study expostulated for the women’s political autonomy. The study also advocated for the improvement of heath and non-health infrastructure for long-term benefit.
Shrabanti Maity did M. Sc in economics with specialization on Statistics and Econometrics from the University of Calcutta and then she gained her PhD degree from The University of Burdwan. She completed her post-doctoral research from Ghent University, Belgium. Currently, she is working as an Associate Professor of Economics at Vidyasagar University, Midnapore. Earlier she was appointed as Assistant Professor of Economics in Assam University (A Central University), Silchar. During this academic journey, she has published more than fifty articles in different reputed national and international journals and edited books. She has supervised five PhD and three M.Phil dissertations. Presently four candidates are pursuing PhD under her supervision. A book entitled, A Study of Measurement of Efficiency, written by her is published by Verlag Dr. Muller (VDM). Her areas of research interest are- Applied Econometrics, Human Development, Gender Studies, and Socio-economic Facets.
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Background: Workplace is associated with exposure to various products, which can be associated with adverse health outcomes. It is true with underground construction work. This study calculated the prevalence of common health problems among Nepalese underground construction workers in comparison to heavy construction workers. This type of study is rare in the context of Nepal and other developing countries and we hope that the findings will help to take precautions for the prevention of these conditions. Method: It was a retrospective study based on the clinical record of outpatient cases and general health check-ups of all Nepalese workers available at the Project clinic, Upper Tamakoshi Hydroelectric Project, Gongar, Bigu, Dolakha. We studied three hundred ninety-eight workers. We used multipurpose analysis and calculated Chi-square test, correlations, odds ratios. Results: 216 (54.3%) participants worked inside the tunnel and 182 (43.2%) participants worked outside the tunnel. Respiratory disease mainly upper respiratory tract infection (URTI) (23.4%) is the most common presentation among construction workers followed by injuries (16.7%). Injuries and hypertension were significantly higher in inside the tunnel workers and acute gastroenteritis was significantly (p-value <0.05) higher in outside the tunnel workers. Other common diseases were acid peptic disease, cutaneous fungal infection, dermatitis, and foreign body eye/ ear.Increasing age increased the chance of hypertension and cutaneous fungal infection among construction workers. Further studies are required for the analysis of risk factors associated with these health conditions. Conclusion: Respiratory problems are the most common health problem in underground construction workers however; injuries and hypertension were significantly higher in tunnel workers. Acute gastroenteritis was significantly higher among outside the tunnel workers. Workplace safety should be the priority of every construction sites especially focusing to prevent respiratory problems, injuries, and accidents.
Education: April 2015-April 2018: MD in General Practice and Emergency Medicine from Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Nepal Nov 2006-May 2013: MBBS from Maharajgunj Medical Campus, Institute of Medicine, T.U including one year internship at Tribhuwan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Jul 2003 -May 2006: +2 science from Caspian Valley College Higher Secondary School, Kumaripati, Lalitpur, Nepal Dec 1991-Apr 2003: School level education up to SLC from Kanchan Secondary English School, Chapagaon, Lalitpur, Nepal Present involvement: Clinical Coordinator, District Hospital, Terhathum, Province 1, Nepal Co-editor, Journal of General Practice and Emergency Medicine of Nepal
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Background: The incidence of abortion in Ghana ranges from 27 per 1000 to 61 per 1000 women, causing gynaecological complications and maternal mortality. The use of modern contraceptives and its associated factors among women aged 15–49 years have been documented. However, utilization of modern contraceptives specifically among women with induced abortion history is underreported. The study therefore aimed at determining the proportion and identifying predictors of contraceptives use in this underreported population. Methods: The study used secondary data from the 2017 Ghana Maternal Health Survey (GMHS) for the analysis.The analysis is on a weighted sample of 3,039 women aged (15–49 years) with a history of induced abortion. Both descriptive and inferential methods were employed. Chi-square test, univariate and multivariate logistic regression techniques were used to assess statistical associations between the outcome variable and the predictors. Statistical significance was set at 95% confidence interval and p values ≤0.05. Results: Out of the 3,039 participants, 37% (95% CI: 34.6, 38.84) used contraceptives. We identified women’ age, union, place of residence, knowledge of fertile period, total pregnancy outcomes, and region as strong significant (95% CI, p ≤ 0.05) predictors of post induced abortion contraceptives use. Conclusion: Contraceptives use among this vulnerable population is low. Therefore, there is a need to provide widespread access to post abortion contraception services and enhance efforts to efficiently integrate safe abortion practices law into health services in Ghana.
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Background: Although community participation remains an essential component globally in healthcare serviceplanning, evidence of how rural communities participate in theplanning of rural-based healthcare programs hasless been explored in Sub-SaharanAfrica. Objective: We explored communities’ participation in health care planning in hard-toreach communities, withinthe context of Integrated Community Case Management(iCCM), a community-based health program implementedin Ghana. Methods: Qualitative data were collected from eleven (11) hard-to-reach communities through Focus GroupDiscussions (FGDs), Key Informant Interviews (KIIs) as well as district-level studies (Nadowli-Kaleo, and WA Eastdistricts of Ghana). The Rifkin’sspider-gram, framework, for measuring and evaluating community participation inhealthcare planning was adapted for the study. The results: The study found that community participation was superficially conducted by the CHOs. A holisticcommunity needs assessment to create awareness, foster a common understanding of health situations,collaboration, acceptance and ownership of the program were indiscernible. Rather, it took the form of an event,expert-led-definition, devoid of coherence to build locals understanding to gain their support asbeneficiaries of theprogram. Consequently, some of the key requirements of theprogram, such as resource mobilization by ruralresidents, Community-based monitoring of the program and the act of leadership towards sustainability of theprogram were not explicitly found in the beneficiaries’ communities. Conclusion and recommendation: The study concludes that there is a need to expand theconcept ofcommunity involvement in iCCM to facilitate communities’ contribution to their healthcare. Also, a transdisciplinaryapproach is required for engineering and scaling up community-based health programs, empowering VHCs, CBHVsand CHAs to realize success.
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Background: Vector-borne diseases transmitted by insect vectors such as mosquitoes occur in over 100 countries and affect almost half of the world’s population. Culexpipienscomplex is the vector of West Nile Encephalitis, Japanese encephalitis, Saint Louis encephalitis, avian malaria and lymphatic Elephantiasis vectors. Vector control using insecticides is recommended, but the emergence of insecticide resistance is threat for control and prevention of vector borne diseases. Understanding of insecticide resistance helps to formulate a global strategy to control insecticide resistance in vectors. Materials and Methods: Worldwide insecticide resistance in these specieswas found by the available papers and map of the data for carbamates, organochlorines, organophosphates, pyrethroids, microbial and insect growth regulator insecticides weredone. An intensive search of scientific literature was done in “PubMed”, “Web of Knowledge”, “Scopus”, “Google Scholar”, “SID”, etc. Results: Results showed a wide variety of susceptibility/resistance status of Culexpipiens complex to these insecticides in world. Discussion: Due to importance ofthis species in transmission of diseases, resistance management strategies should be further considered in to prevent from insecticide resistance and replacement of novel approach for vector control.
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Scope and background: Every year more than 7,95,000 people in USA are victims of cerebrovascular accident, majority being ischemic. There is hypothesis that lipid abnormalities have modifiable risk relationship with stroke subtypes. Elephant in the room; Comparing total cholesterol, HDL-C and their ratio among ischemic and hemorrhagic stroke. Study Design: An observational prospective comparative study. Methodology: Hundred patients between 30 to 90 years of age, admitted in BVH Bahawalpur with first ever CVA and verified by CT scan brain, were included in the study. Patients with history of coronary heart disease or lipid lowering drugs, epilepsy, infective or metastatic disorder, or pre-existing cognitive defects, were excluded from this study. A medical history with neurological examination was recorded and subjects were broadly divided in 50 each participant of ischemic (group A) and hemorrhagic (group B) subtypes. Fasting total cholesterol (TC), high density lipoproteins (HDL-C) and triglycerides (TGs)of both groups were collected and mean values of quantitative data were presented as mean SD [standard deviation].The lipid values were interpreted in normal or high-risk category by applying NCEP ATPIII criterion. Frequency percentage of values was determined and compared using proportion test taking p-value of < 0.05 as significant. Results: Quantitative lipoprotein data showed that in group A (ischemic CVA), mean TC was 218.30 ± 79mg/dl and raised above normal reference range. While it was 194± 26.7mg/ dl in hemorrhagic cases (highly significant at P value of < 0.001). The mean HDL concentration was 33.10± 7.33mg/dl in patients of ischemic stroke while it was 40.02-4.22 in hemorrhagic cases (p value o.oo2, highly significant). Serum TGs levels turned out to be normal in both groups. Conclusion: Hypercholesterolemia and low HDLC was seen significantly in ischemicCVA group as compared to hemorrhagic counterpart so needing timely preventive lipid lowering strategies.
Kindness is always free, so working in health care system is most noble job in society. My name is drmuhammad Alamgir and I am currently posted as assistant professor of medicine in corona dedicated hospital in Bahawalpur, Pakistan, I graduated from Quaid-e-Azam medical college in 1989 and worked as resident, senior registrar and consultant in Bahawal Victoria Hospital, Pakistan. I earned credentials of MCPS and FCPS in 2005 while currently studying health profession education program. I have long integrating experience in patients care, consultation and teaching medicine to undergraduates. Teachers have main role in character building, behavior development and ethics. My passion is strategic research work and about 10 papers are published in reputable journals; In spare time I may prefer studies and giving time to family. My core professional belief or value is serving ailing humanity because “serving others is rent you pay for your room in heaven”.
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In a bid to slow the rate of spread of the virus, the Federal Government of Nigeria, on several occasions, imposed targeted lockdown measures in areas with rapid increase of Covid-19 cases. The states in which the federal government imposed the targeted lockdown included Lagos, Ogun, and the Federal Capital Territory in Abuja. Some States in the country imposed partial lockdown and closure of interstate boarders. Curfews have also been introduced in all the states nationwide. To alleviate the effects of the lockdown, the Federal Government of Nigeria rolled out palliative measures for targeted groups. However, lamentations have trailed the distribution of government palliatives by the masses. Citizens allege that the process of distribution of palliatives had been politicized.
Isaac Omo-Ehiabhi Eranga is an alumnus of Center for Bioethics and Research. He bagged degrees in Philosophy and Theology and he's the founder of Center for Cancers Awareness Campaign Nigeria.
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This presentation examines the question of why the pattern of narcissistic object-relating (collusion) develops early in life and how it may impact the lifelong process of individuation. The scope of the presentation is limited to the study of the narcissistic relational pattern, being a neurotic self-defense organization of the psyche, and its potential influence on the process of individuation. Narcissistic adult couple relationships are one of the arenas in which unresolved aspects of the past, alive in the present, are unconsciously brought and endlessly repeated with intensity. Adult relationships are often formed in the hope that both partners will wipe out their old wounds. However, despite apparent differences in overt social functioning, people unconsciously tend to select partners who are at the same basic level of personality differentiation, but who have opposite patterns of defensive organization. Primitive defences and projections, which are played out by the narcissistic couple, become a substitute for true identity. These dynamics inhibit the ability of the ego to gain access to the unconscious, and the Self to get access to the ego, disrupting the possibility of emergence of a dialogical relationship. This process creates obstacles to growth and individuation, which leads this author to suggest the notion of ‘impeded individuation’ in narcissism.
Karolina Nørby, M.Sc., M.A., (Denmark) is a Jungian Analyst who devotes her time between maintaining a busy analytical practice in Copenhagen and lecturing on the subjects of Jungian psychology and psychotherapy. Karolina’s main area of professional interest is the interface between western Jungian analytical psychology and the eastern practices of meditation and mindful presence. In her opinion, an integrative approach to mental healthcare, based on a combination of these two approaches, can address the profound need for a more in-depth and person-centred approach to modern mental healthcare.
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Objective: Our study aimed to determine the effect of a digital divide in the adoption of online patient portals by the motivated patients who wish to improve their health outcomes by use of internet and information technology, to assess determinants of low adoption rates of online portals, and to explore social media use as a correlation to patient portal use. Methods: We utilized data from the Health Information National Trends Survey (HINTS, 2017 and 2018). We performed a cross-sectional study analyzing the outcome variable of patient portal use with several predictor variables: age, marital status, gender, mental health, education, Medicaid, income, number of people in household, trust, social media, chronic disease, and health app use. Basic descriptive statistics and logistic regression were performed using SPSS version 25. Results: Our study found that low adoption rates go beyond the digital divide. Previously identified digital divide factors like health insurance type, age, and chronic disease, which are determinants of patient portal use in the general population, were not significant predictors in our motivated sampled population. The study also found that a correlation exists between social media use and patient portal use. Conclusions: Many of the factors previously identified by the literature may not be a barrier to patient portal use by self-motivated individuals, which underscores the importance of self-motivation inpatient portal use. Behavioral/ motivational interventions and improvement in its usability geared towards adopting online portals can improve its public health significance.
Ahmed is an advocate of 360 degrees digital health evaluation. A holistic methodology of digital health outcome evaluation emphasizing its impact on public health improvement and health disparity. He is presently a clinical informaticist/clinical instructor at the Icahn School of Medicine at Mount Sinai Hospital in New York. He champions various electronic health record optimization projects for efficiency and clinical workflow improvement.
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Background: Colorectal cancer (CRC) is the third leading cause for cancer worldwide. Prevalence of CRC is increasing in post -Soviet countries (PSC). European guidelines encourage member countries to allocate resources for primary prevention of CRC through screening. Though, cost-effective screening is becoming a priority. Methods: A framework for health priority determination to prioritize CRC screening was developed. Public health websites were accessed to abstract epidemiologic data for PSCs. The framework included prioritization by absolute risk (incidence, prevalence), relative risk (CRC ranking for national cancer deaths) and population attributable risk for the disease. Risk indicators were identified for PSC. Further detailed risk assessment by Z scoring was completed to assess CRC disease burden. Statistical analysis was performed for correlation. Variables included in risk assessment were population, life expectancy, gross national income per capita, percent GDP spent on health expenditure, total expenditure on health per capita, age standardized mortality to incidence ratio, cancer ranking by incidence and smoking prevalence. Results: Ideal risk assessment can assess the disparities related to CRC burden. The risk assessment showed difference in CRC burden amongst the PSC. Armenia, Belarus, Georgia and Kyrgyzstan have high burden with risk scores ranging from 2-5. Though Latvia and Lithuania have some CRC burden, the risk score is mitigated by expenditure on health and improved mortality to incidence ratio because of CRC screening. On the other hand, Tajikistan with some risk factors had most of its score decreased by the CRC mortality ranking of 22nd indicating a very low CRC burden. Conclusion: Risk assessment score could be an arbitrary measure to evaluate inter regional variability in CRC burden.Identifying high CRC burden countries to prioritize screening is important. Uniform and comparable CRC risk indicators for the region is needed. Health need assessment and priority setting is important for better distribution of resources.
Rebecca Pratiti works as a faculty physician with McLaren Health Care, Flint. She had recently completed her Master’s in Public Health. She is interested in epidemiology and occupational health. Her most recent projects have been about the harms of hookah smoking, biomass cookstove related indoor air pollution health effects, colorectal cancer effect on public health and developing epidemic outbreak questionnaire.
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Thomas Kuhn in his book, The Structure of Scientific Revolutions, defines paradigm “as a philosophical and theoretical framework of a scientific school or discipline within which theories, laws and generalizations and experiments performed in support of them is formulated”. The health paradigm for the last two and half centuries has been a bio-medical paradigm that pursues the search for good health as mainly the absence of disease. The criteria for interventions are that they are reliable, replicable and valid. Thus, health improvements are based on interventions that are linear, predictable and generalizable. Challenges to this view were catalyzed in 1978 at Alma Ata by member states of the World Health Organization adopting Primary Health Care (PHC). PHC was based on the principles of equity and community participation, approaches that revolutionized the ideas of how health improves. This approach has rapidly gained traction during the COVID-19 pandemic where the bio-medical paradigm has failed to halt the still spreading virus. More information and publications are giving evidence that a new approach is needed focusing on equity, community participation, governance, and social justice. Is a new paradigm for health improvements able to replace the old one? This presentation reviews the main attributes and values of both paradigms and examines whether a paradigm based on social determinants and rights base approaches can and will replace the bio-medical paradigm. It will highlight the strengths and weaknesses of a new paradigm and the challenges for change.
Susan Rifkin is an Adjunct Professor at the Colorado School of Public Health, a Senior Associate at the Bloomberg School of Public Health, Johns Hopkins University and on the faculty of the London School of Hygiene and Tropical Medicine. She has helped to establish two Masters degree Programs in Public Health --one at the University of Heidelberg and one in Kisumu Kenya. She has done consultancy work for WHO, UNICEF, World Bank and the European Union. Her research interests are focused on health policy, Primary Health Care, community participation and empowerment, in low and middle- income countries. She has published widely in The Lancet, Health Policy and Planning, BMJ Global Health, and Social Science and Medicine.
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Thomas Kuhn in his book, The Structure of Scientific Revolutions, defines paradigm “as a philosophical and theoretical framework of a scientific school or discipline within which theories, laws and generalizations and experiments performed in support of them is formulated”. The health paradigm for the last two and half centuries has been a bio-medical paradigm that pursues the search for good health as mainly the absence of disease. The criteria for interventions are that they are reliable, replicable and valid. Thus, health improvements are based on interventions that are linear, predictable and generalizable. Challenges to this view were catalyzed in 1978 at Alma Ata by member states of the World Health Organization adopting Primary Health Care (PHC). PHC was based on the principles of equity and community participation, approaches that revolutionized the ideas of how health improves. This approach has rapidly gained traction during the COVID-19 pandemic where the bio-medical paradigm has failed to halt the still spreading virus. More information and publications are giving evidence that a new approach is needed focusing on equity, community participation, governance, and social justice. Is a new paradigm for health improvements able to replace the old one? This presentation reviews the main attributes and values of both paradigms and examines whether a paradigm based on social determinants and rights base approaches can and will replace the bio-medical paradigm. It will highlight the strengths and weaknesses of a new paradigm and the challenges for change.
Susan Rifkin is an Adjunct Professor at the Colorado School of Public Health, a Senior Associate at the Bloomberg School of Public Health, Johns Hopkins University and on the faculty of the London School of Hygiene and Tropical Medicine. She has helped to establish two Masters degree Programs in Public Health --one at the University of Heidelberg and one in Kisumu Kenya. She has done consultancy work for WHO, UNICEF, World Bank and the European Union. Her research interests are focused on health policy, Primary Health Care, community participation and empowerment, in low and middle- income countries. She has published widely in The Lancet, Health Policy and Planning, BMJ Global Health, and Social Science and Medicine.
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Introduction: Changes in the nature of warfare hasaltered the health consequences among veterans. We planned to understand the demographic changes in the active-duty service member profile prior to and following September 11, 2001 (9/11).We analyzed the diagnosis of posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) as recorded in service-connection ratings (percent disability). Methods: A retrospective cohort-study of military veterans who received care at Veterans Health Administration medical centers between December 1998 and May 2014 using clinical data from the Corporate Data Warehouse. Results: A cohort of 1,339,937 veterans who received an inpatient/outpatient diagnosis of PTSD and/or TBIwas divided into 4 service period groups and 3 diagnosis categories. The service periods included pre-9/11 (n = 1,030,806; 77%), post-9/11 (n = 204,083; 15%), overlap-9/11 (n = 89,953; 7%), and re-entered post-9/11 (n = 15,095; 1%). The diagnosis categories included PTSD alone (n = 1,132,356; 85%), TBI alone (n = 100,789; 7%) and PTSD+TBI (n = 106,792; 8%). Results of the post-9/11 group revealed significant changes, including (1) increase of veterans with PTSD+TBI; (2) increase of female veterans with PTSD+TBI; and (3) increasedlevel of severity of diagnosed PTSD/ TBI evidenced by higher service-connected disability pensions at younger age in the post-9/11 group and; (4) unequal distribution of veterans with PTSD+TBI across geographic areas. Conclusions: The veteran of the post-9/11 period does not mirror the pre-9/11 period. Findings are valuable for policy making, allocating resources, and reconsidering the paradigm for treating veterans with these injuries recognising: (a) increasing number of veterans with PTSD, TBI and associated multisystem issues, (b) increasing number of female veterans, (c) increasing number of younger veterans with higher disability pensions (d) geographical areas with disproportionate numbers of veterans. Conflict of interest statement: The authors report no actual or potential conflicts of interest with regard to this article.
• Retired from VA after 32 years and 21 years of service in Army Reserve and 6 deployments. • Former Clinical Director of PTSD Program and Assistant Clinical Professorat VAMC. Former Medial Director of Restorative Brain Clinic. Passionate working with war veterans, service members with PTSD, TBI and deployment related behavioural health issues and teach people how to overcome adversities. • Dedicated life to mind body medicine and teach people preventive lifestyle changes to live long healthy lives. • Author of three books with latest book, “Innovative Holistic Approaches to PTSD and Life stress” based upon studies of hundreds of people who were resilient despite going through numerous traumatic events. • Recipient of “Legion of Merit,” award and “Order of Military Medical Merit”. • Iraq, Afghanistan War Veteran, worked in Germany, Japan and Guatemala as Army physician.
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This qualitative explanatory case study assessed the influence of Official Development Assistance on selected health development indicators in Uganda between 2005 and 2013 by reviewing development partners’ perceptions. Key health indicators included: (a) under five- year-old mortality rates, (b) infant mortality rates, and (c) maternal mortality ratio. Results indicated slow progress in reducing infant mortality and under-five mortality rates, and almost no progress in the maternal mortality ratio despite the disbursement of a yearly average of nearly $400 million USD in the last 7 years to the health sector in Uganda. Five bottlenecks in the influence of development assistance on health indicators were identified: (a) poor governance and accountability in health care system in Uganda, (b) ineffective supply chain of health commodities, (c) negative cultural beliefs, (d) insufficient government funding to health care, (e) insufficient alignment of development assistance to the National Development Plan, and non-compliance with the Paris Declaration on Aid Effectiveness.
Dr Cyriaque Sobtafo is currently serving with the United Nations as Senior International Development Experts. He has over 25 years of experiences assisting developing countries in their efforts toward achieving sustainable developments. Dr Sobtafo has served in various parts of the world, including Africa, North America, Europe, the Balkans and Oceania, working both in development and humanitarian contexts. He hold a PhD of Management from the School of Advanced Studies at the University of Phoenix (US), a Dynamic Leadership certificate from Harvard Business School (US), a Master’s degree in food technology from ENSAI of the University of Ngaoundere (Cameroon), and various certifications in development discourse from various universities.
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While the correlation between diabetes during pregnancy and birth defects is well-established, how hyperglycemia causes developmental abnormalities remains unclear. In this study, we developed a novel "hyperglycemic" chicken embryonic model by administrating various doses of glucose to fertilized eggs at embryonic stages HH16 or HH24. When the embryos were collected at HH35, the LD50 was 1.57 g/Kg under HH16 treatment and 0.93 g/Kg under HH24 treatment, indicating that "hyperglycemic" environments can be lethal for the embryos. When exposed to a dose equal to or higher than 1 g/Kg glucose at HH16 or HH24, more than 40% of the surviving chicken embryos displayed heart defects and/or limb defects. The limb defects were associated with proliferation defects of both the wing and leg buds indicated by reduced numbers of p-H3S10 labeled cells. These limb defects were also associated with ectopic apoptosis in the leg bud and expression changes of key apoptotic genes. Furthermore, glucose treatment induced decreased expression of genes involved in Shh-signaling, chondrogenesis, and digit patterning in the limb bud. In summary, our data demonstrated that a high-glucose environment induces congenital heart and limb defects associated with disrupted cell proliferation and apoptosis, possibly through depressed Shh-signaling.
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Background: The implications of disease in human are mostly addressed from the progression stage. For instance, Colorectal cancer is mostly diagnosed at age 50 years and above for non-hereditary colorectal cancer. Insufficient attention has been focused on understanding the early progression of diseases, particularly colorectal cancer, prior to the age in which most diagnosis occurs. Homeostasis biomarkers have not been given enough attention. Importantly, one of the key elements in homeostasis, glutathione, and its associated operating genes, have not been well elucidated in disease initiation, promotion, and progression. Additionally, the interplay theglutathione pathway has with other physiological functions and how they orchestrate in homeostasis is yet to be fully elucidated. Methods: Targeted quantitative analysis was performed on 41 samples of colon cancer and normal cell lines using capillary electrophoresis mass spectrometry (CE-TOFMS and CE-QqQMS) in the cation and anion analysis modes for analysing cationic and anionic metabolites, respectively. A total of 116 metabolites (54 and 62 metabolites in the cation and anion mode, respectively) involved in glycolysis, pentose phosphate pathway, tricarboxylic acid (TCA) cycle, urea cycle, and polyamine, creatine, purine,glutathione, nicotinamide, choline, and amino acid metabolisms were annotated based on the HMT metabolite database. Results: In both colon cancer cell lines, HCT-116 and HT-29, there were treatment effects from the addition of fiber and bile acids. Bile acid-A alone appeared to increase oxidative stress, osmotic stress, drive ATP demand and increase NAD+/NADH ratio – consistent with a tumor promoter role. Bile acid-B alone decreased levels of oxidative and osmotic stress and energy demand. Bile acid-B magnified decrease levels of oxidative and osmotic stress and energy demand when Bile acid-A and/or Fiber was added. The effects were similar between HCT-116 and HT-29, but not duplicative, as these are two different cancer cell lines. Conclusion: HCT-116 and HT-29 are colon cancer cell lines that exhibit proliferation in culture. Metabolomic profiling exhibits osmotic, energy and oxidative stress in these cell lines compared to normal colon cells. With different combinations of bile acids and fibres, it has been demonstrated that cellular stress in the colon cancer cells can be reduced to more normal levels.
BeneEkine-Afolabi is a graduate of River State University of Science & Technology in Applied Biology (Medical Microbiology option); with an MRes degree at University of East London, United Kingdom. She had her PhD. study & worked at the Department of Natural Sciences, Middlesex University, UK. Trained in practical approach to toxicology in drug development (American College of Toxicology/British Toxicology Society). Bene does research in Microbiology, Molecular Biology and Cancer: Her current focus of research (which has yielded eight designed models), is on the Investigation of molecular mechanism of colorectal cancer and due to the current pandemic, has been involved in drug development for COVID-19. Bene had Harvard University part-sponsored training in therapeutic research in Cancer Biology & Therapeutic. Bene has been involved in three published peer reviewed article, two manuscript awaiting publication, among which one is on COVID-19 and was submitted to the Chief Medical Officer of United Kingdom to assist in response to the pandemic.
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Objective: To understand the health-seeking experience of individuals with morbid obesity in search of bariatric surgery in the public healthcare system. Methods: This was a qualitative study based on social phenomenology with 17 individuals with morbid obesity, hospitalized, and scheduled for bariatric surgery in a public hospital in the city of São Paulo, Brazil. Interviews were carried out based on the following guiding questions: How was your search for bariatric surgery? What are your expectations after the surgery? Results: Individuals with morbid obesity in search of bariatric surgery have (i) experienced a health-seeking itinerary in public healthcare services; (ii) dealt with long waiting times for surgery, which contributed to weight gain and triggered biopsychosocial issues and limitations in their daily lives; (iii) felt careless due to the gap between the care received and that recommended by health policies, programs, and guidelines; (iv) considered the assistance of health professionals essential for them to navigate the health itinerary and obtain approval for bariatric surgery; and (v) expected structural improvements in the healthcare network and care practices carried out by a trained multidisciplinary team; and (vi) expected a reduction in the gap between the care delivered by the public healthcare service and the therapeutic itinerary experienced by them. Conclusion: When following a health-seeking itinerary for bariatric surgery, individuals with morbid obesity experienced difficulties and obstacles that led them to seek and use resources that were not always available in the healthcare system. The aspects involved in such an itinerary highlighted a need of strengthening the care flow in the healthcare system and investing in professional training to reduce inequalities in access to bariatric surgery, which can substantially increase the quality of care delivery through interventions that encourage autonomy and self-management of the body weight.
C. A. Conz has a degree in Nursing from the University of Sagrado Coração (1992); a master’s degree in Nursing from the University of São Paulo School of Nursing (2008); and a Ph.D. degree in Science from the University of São Paulo School of Nursing (2019). Currently, she is a professor in the Graduate Program of the Centro Universitário São Camilo at Faculdades Metropolitanas Unidas and has a temporary assistant professor position at the University of São Paulo School of Nursing. C. A. Conz has experience in the field of Nursing, with an emphasis on Intensive Care Nursing, and has worked mainly on the following topics: adult, pediatric, and neonatal intensive care nursing. Research area: individuals with obesity.
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Technology has just as much potential to unleash humanity as to replace or hinder it. Technology enables mega-shifts that redraw not only commerce, culture and society, but also our biology and ethics. Health technologies aim to improve individual and population health but appears to exacerbate health disparities in its current state. Even in the surging of digital advancements, it is known that health technologies benefit some groups more than others. A lack of acknowledgment of these inequities could lead to their further propagation and widen the digital divide by disproportionately not providing beneficial technologies to marginalized groups that already have health-related disadvantages. These fundamental technology contributors to health disparity can be mitigated. Be aware and care: Big data and data science: There are concerns about whether applications of big data research will help to reduce existing health disparities or whether they might inadvertently exacerbate these disparities. Analyses of big data have the potential to elucidate ways in which socioeconomic status, race and ethnicity, and other social determinants of health (SDOH) contribute to disease/disorder incidence and outcomes. Also, may identify promising avenues for intervention. However, the underrepresentation of minority and vulnerable populations in big datasets and inappropriate data analyses have the potential to generate biased and inaccurate conclusions that threaten equitable progress in biomedical research and health care. Data curation and missing metrics: To eliminate health disparities, it is critical to first know where the disparity exists. Many health care data platforms miss critical information regarding the person, such as race/ethnicity, primary language spoken, and written language. Yet, have a requirement to collect. Also missing are the social determinants of health (SDOH). SDOH are shaped by the distribution of money, power, and resources at global/national/local levels, and are major drivers of health inequities, including differences in health status. SDOH are powerful influences on health outcomes as most recently demonstrated by covid. In addition, there is no requirement to collect this information in a standardized way or to harmonize semantics to enhance interoperability. Deficiencies in racial and ethnic data may prevent providers from conducting meaningful risk stratification for chronic diseases or acute conditions more prevalent in certain groups. Incomplete data makes it more difficult for providers to create meaningful population health management plans that address the specific needs of their communities. These mitigatable deficiencies needlessly contribute to health disparities, The ability to stratify reporting of health quality measures, to target disparities, and to understand effective interventions or strategies for addressing disparities depends on the ability to curate this information consistently with common semantics and data models. Unintentional analytic biases: Most organizations are committed to avoiding harms due to data paucity, biased designs, and inappropriate analytics. Assumingly, most biases are accidental and negligent, not intentional. However, all data is immutable and models do precisely what taught to do. Big data analytics advances the use of artificial intelligence, machine learning, deep learning and natural language processing. These tools often require algorithms, pattern recognitions and language management, which have been plagued with biases regarding vulnerable populations. Some of these biases are due to poorly designed algorithms, measurement mishaps, and mismanaged training, which can cause second order harms, such as loss of opportunity, medical harm, economic loss, loss of liberty and social detriments, that exacerbate health disparities. These too can be mitigated to provide appropriate health care to all populations. Summary: Most contributors to health disparities can be mitigated. Now is the time to address data collection, curation, management, analytics, interpretations, and application issues to eliminate health disparities. Without this mitigation in the science of data technologies, health disparities will be more burdensome to self and to society.
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The Guideline for Good Clinical Practice (ICH GCP) is beingrevised to address concerns about its utility, but this may take years. In this article, we showcase existing examples of sensible and workable national policy for clinical trials inEurope, the United States and Australia. We highlight that ICH GCP is not a legal requirement in any of these regions andcall for the ICH Committee to build into the next version of ICH GCP, the flexibility already present in many national regulatory frameworks.Whilst the principles laid down in ICH GCP form the bedrock for trial conduct internationally, we examine whether some of its detail is truly evidence-based. We also question whether a Guideline co-created by the PharmaceuticalIndustry and Regulators can ever reflect the views of the stakeholders it impacts. Flexibility in the way ICH GCP is applied is especially critical for low-risk, comparative effectiveness trials. These trials have the potential to rapidly improve public health and reduce the healthcare cost but are currently mired in levels of bureaucracy that unnecessarily hamper the generation of the evidence needed to do so. We use key trial activities, including informed consent and safety reporting to illustrate how a proportionate approach to regulation could create an agile framework that facilities these trials whilst still protecting trial participants.
Tanya Symons has worked in the field of clinical research for over 25 years as a researcher and as a government consultant in the United Kingdom and Australia. Her outputs include the National Institute of Health Research (NIHR) Clinical Trials Toolkit, an internationally recognised resource designed to help researchers navigate the complex regulatory requirements for clinical trials. In Australia, she has authored several national guidelines including the National Health and Medical Research Council (NHMRC) Guidance: Safety monitoring and reporting in clinical trials involving therapeutic goods, the Australian Clinical Trial Alliance’s Consumer Involvement and Engagement Toolkit and co-authored the Therapeutic Goods Administration (TGA) Australian Clinical Trials Handbook.Tanya has also provided Good Clinical Practice training to many biomedical research organisations in the UK and Australia. Her current research interest (and the topic of her PhD) is using proportionate consent models in a Learning Healthcare System.
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Female patients with urogenital prolapse and gynecologists need to take treatment decisions that are often unpredictable regarding impact on the future everyday lives of the patients. Shared decision-making (SDM) elicits patients preferences in order to share decisions and involve patients actively into the decision making process. The aim of this study was to develop a feasible IT-based instrument to support the dialogue and SDM between patients and gynecologists during consultations. The instrument should elicit and weight patients’ preferences and combine these with evidence into ranked treatment options that were presented during consultations. Methods: The study had a design of user‐ involving field research and a development phase using the contextual design method together with the participatory design technique of prompting cards. Observations, ten exploratory interviews and five workshops prompted for emotional stories and identified the users’ needs. Five additional workshops decided for evidence and best estimates for the instruments algorithm. The design process tested for usability of the instrument in an iterative process (Figure 1). Results: Data was collected from four Danish gynecology outpatient clinics. Content analysis led to important themes and 16 criteria for the home-based preference-sensitive questions. For the patients three themes emerged: 1) how the impact of symptoms on everyday life affected the need for relief, 2) their bodily perception and sex life and 3) their worries about the future (table 1). For gynecologists the different symptoms and their severity was a main theme. Conclusion: The study demonstrates how user involvement informed the prototyping process and how patients’ preferences could be included in the final prototype through an algorithm. The developed algorithm, the eliciting questions and a graphical presentation in the patient’s health record gave way to each patient’s individual preferences and her involvement in the decision-making process.
Mette Hulbaekregistered as a nurse in 1992, from Bispebjerg Nursing Academy, Copenhagen. She performed specialisturogynecologypatient care within urodynamic evaluations and urinary- and fecal incontinence since 2000. The last ten years at the department of Gynecology and Obstetrics, University Hospital of Sønderjylland, Denmark. She holds a PhD degree from Southern University of Denmark in Health Science entitled ‘Developing and testing an online tool for patients with pelvic organ prolapse to support shared decision making’. Her work evolves around patient involvement and the concept of shared decision-making especially for patients with pelvic floor disorder and their multidisciplinary consultations. She was a founding member of the first international society in 2018 for shared decision making in healthcare - the ISDM Society (the International Shared Decision Making Soc.) and for several years board member of the Danish Patients Continence Society working for increased patient involvement in their incontinence care.
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Objectives: To investigate the relationship betweet a prostasin gene variations and the development ofpreeclampsia in a Pakistani female population. Methods: This was a case-control study carried out atUniversity of Karachi, Karachi, Pakistan between May2018 and 2019. A single nucleotide polymorphism(SNP) at rs12597511 locus was examined withpolymerase chain reaction (PCR) and restrictionfragment length polymorphism (RFLP) analysesin 76 preeclamptic and 74 normotensive expecting mothers. Results: We observed significantly increased risk ofpreeclampsia associated with the CC genotype ofrs12597511 polymorphism as compared to TT(p<0.001, OR=8.08, 95% CI: 1.28-31.19) andTT/TC (p<0.001, OR=14.66 and 95% CI: 3.31-65.07) genotypes carriers. Calculation of the allelic distribution revealed a higher frequency of the T allele (82%) among controls; however, the C allele was more prevalent in the preeclamptic group (36%) significantly. Conclusion: The significantly higher C allele frequency in the prostasin gene at the rs12597511 locus in the preeclamptic group indicates that the distribution of the C allele of the prostasin gene is a potential risk factor contributing to the development of preeclampsia.
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Introduction: The maternal mortality rate in Surabaya in the last 3 years has decreased significantly, but it is still quite high at 79.40 per 100,000 live births in 2017. Even though it has shown good progress, Surabaya still occupies the second largest maternal mortality rate in the province East Java. The causes of maternal deaths included 3 being late (late in making a decision, late arriving at a health facility and late in receiving medical help). Indept interview results in 6 Puskesmas in Surabaya, one of the other problems that risked causing maternal death was in the process of referring to the mother giving birth, because the Puskesmas had difficulty getting hospitals with available resources to accept the condition of the pregnant women to be referred. The issue of referral communication between the Puskesmas and the Hospital has become very important to be resolved, one of which is by developing a mobile app system in finding hospitals available for their resources to accept the condition of pregnant women to be referred. The main function of this mobile app is to reduce the risk of death for the mother in the delivery process. The purpose of this study is to develop a mobile app system framework for the maternal referral system. Methods: The mobile app is compiled with the user of the Puskesmas midwife and the IRD officer of the referral hospital. This mobile app is compiled based on the results of the FGD with midwives, doctors and puskesmas heads about the referral system regulation contained in Surabaya City and FGD with obstetricians who agree on several indicators of maternal conditions that must be considered in the referral process and also refer back. This mobile app was developed with internet communication and SMS media with the default internet. So if the gadget is out of reach of the internet, then broadcast the message using the SMS feature. This automation was developed so as not to inhibit the sending of messages in an emergency. Result and Discussion: The communication flow of this mobile app is to order emergency conditions at the puskesmas puskesmas to the hospital through the mobile app system, the available hospital resources based on the condition of patients being broadcasted responding to messages through the mobile app system, patients are referred and treated in hospitals. The process will end with referring back to the Puskesmas as a control service after giving birth. This mobile app has gone through a trial and development process currently in the process of structuring the mobile app based on the bugs that occur in the system. Conclusion: This mobile app still needs development, especially in minimizing system bugs, because this mobile app-based referral system requires fast and accurate communication.
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Background: Nurturing a child with Autism Spectrum Disorder (ASD) can cause major distress. As a result, these parents tend to experience a poor quality of life (QoL) compared to those raising typically developing (TD) children. Objectives: To evaluate the factors which affect the QoL of parents raising children clinically-diagnosed with ASD in Jeddah, and to provide knowledge for the establishment of comprehensive policies and projects that can improve their mental well-being. Materials and Methods: A cross-sectional study design was utilized to assess 200 parents of children clinically-diagnosed with ASD at least 3 months prior to the research. A self-administered WHOQOLBREF questionnaire was employed to assess the QoL of participants through four domains, namely physical health, psychological well-being, social relationships, and environment. Results: Most of the participants were female (58.5%), married (87.0%), and employed (56.5%). Majority completed high school (68.5%), lived in the city (95.5%) and rented their homes (88.5%). Quality of life was significantly affected by gender, employment, social status, and educational attainment of participants. Parents with higher educational attainment and employment and social status exhibited better. Furthermore, female parents experienced lower QoL and more depressive symptoms than males. Conclusion: Gender, educational attainment, and both employment and social status significantly affected the QoL of parents raising children diagnosed with ASD. Furthermore, improving the physical health, psychological, social relationships, and environment of these parents would give them a better QoL and health satisfaction.
Dr. Abeer Ahmad Subke is 40 years old Saudi female Senior Registrar Physician working in Ministry of Health in Jeddah, Saudi Arabia. She holds a Bachelor degree in Medicine and general Surgery from King Abdul Aziz University in Jeddah, 2007. Her passion in quality of care has motivated her to attain a post graduate Diploma in Healthcare Quality Management from the American University in Cairo, 2010. That was followed by attaining a higher level of recognition by becoming a Certified Professional in Healthcare Quality (CPHQ) since 2012 till present. Recently she has become Board certified from the Saudi Board in Preventive Medicine, 2020. Currently she is a Senior Registrar in Ministry of Health and working as an Academic staff in the Joint Program of Preventive Medicine in Jeddah.
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Background: Chronic obstructive lung disease (COPD) is a very serious and common chronic condition. Not all patients having COPD are referred to rehabilitation even though they can benefit from rehabilitation initiatives. Scope: The overall objective of this research project is to ensure referral and uptake for COPD rehabilitation. We focus on detangling the processes in the cross-sectorial workflow of patients with COPD to understand why most patients are not referred to rehabilitation. Methods: We used the functional resonance analysis method (FRAM) to map referring routines from hospital to municipality. We furthermore facilitated cross-sectorial relational coordination by establishing local-and cross sectorial network groups. Results: We found that staff at the hospital and the municipality had different understandings of what rehabilitation is, and they used different words for the same services. Furthermore, hospital staff lack knowledge of what the municipality has to offer patients with COPD. The network groups revealed flaws in the referral system which needed to be adjusted. Conclusion: The FRAM analysis showed how the work was done in real life and detangled factors important to the collaboration. Based on the FRAM the municipality and hospital had a workshop where they agreed to on activities that should be set up to improve the cross-sectoral relations. This resulted in a simplified referral procedures, however ongoing adjustments are made continually based on recommendations from the network groups.
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Background: Intestinal infectionsremain a majorpublichealthburden in developing countries. Due tosocial, ecological, environmental and culturalconditions, Indigenouspeoples in Colombia are at particularly high risk. Materials: 137 stool samples were analyzed by microscopy and realtime-Polymerase Chain Reaction (RT-PCR), targetingprotozoanparasites (Giardiaintestinalis, Entamoebahistolytica, Cryptosporidiumspp., and Cyclosporacayetanensis), bacteria(Campylobacterjejuni, Salmonella spp., Shigellassp./enteroinvasive E. coli (EIEC), Yersiniaspp., enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli ( EPEC), enterotoxin-producing E. coli(ETEC), enteroaggregative E. coli (EAEC), and Tropherymawhipplei), andhelminths (Necatoramericanus, Strongyloidesstercoralis, Ascarislumbricoides, Ancylostomaspp., Trichuris. trichiura, Taeniaspp., Hymenolepisnana, Enterobiusvermicularis, andSchistosomaspp.). Microscopy found additional cases of helminthinfections. Results: At least one pathogen was detected in 93% ofthesamples.The overallresultsrevealedprotozoa in 79%, helminths in 69%, andbacteria in 41%. G. intestinalis (48%), Necator/hookworm (27%), and EAEC (68%) werethemostcommon in eachgroup.Noteworthy, T. whipplei was positive in 7% and T. trichirua in 23% ofthesamples. A significant association of one infection promoting theother was determinedfor G. intestinalisand C. jejuni, helminthinfections, and EIEC. Conclusions: The resultsillustratethe high burden of gastrointestinal pathogens among Indigenous peoples compared too the developing countries.Counter measures are urgently required.
1992 – 1998 Friedrich-Wilhelms-University Bonn, Faculty of Medicine 2001 Thesis, Medical Clinic University Bonn, 2002 – 2003 Postdoctorate: Department of Environmental Health/Medical Center, Division of Toxicology, University of Cincinnati, USA 2003 – 2005 Grünenthal GmbH, Corporate Regulatory and Safety Affairs, Division Clinical Safety, Research and Development, Aachen, Germany 2005 – 2008 Medical Clinic University Bonn, different departments (e.g. ICU, Oncology, General Internal Medicine, Outdoor Patients Department) 2006 Diplomafor Tropical Medicine (DTM), Hamburg, Germany 2006 Degreeas Emergency physician 2008 Specialty in Internal Medicine 2008-2009 Charité – University Medicine Berlin, Institute for TropicalMedicine 2009 - 2010 University Rostock, Department of Tropical Medicine andInfectiousDiseases 2010-2011 Heinrich-Heine University Düsseldorf, Department of Gastroenterology, Hepatology and Infectious Diseases, Ward forInfectiousDiseasesand Tropical Medicine 2010 Qualificationfor Travel medicineandVaccinations 2011 - 2012 Adama-University, Medical Campus, School ofHealthand Hospital, Asella/Ethiopia, Long-term Lecturer, promotedbythe German Academic Exchange Service (DAAD) 2012 Degree in Tropical Medicine 2013 Degree in Infectiology 2013-2015 Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Project Manager forthe European Fund for regional development (EFRE) program, Study in Colombia 2015-now Project Manager at the Medical Mission Institute, Focus on Neglected Tropical Diseases, patented Chagas-Real-Time PCR.
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Background (Introduction): COVID-19 has caused serious damage in every country around the world. Some countries have implemented a lock down for a short period seeking to both address the COVID-19 issue while carrying out economic activities. Vaccinations have also begun in some countries, but a significant effect has yet to be seen. Rather, in actuality infections continue to increase at a slow pace. Objective (Purpose): Although lock downs and limits on operating hours for restaurants have been implemented, infection clusters originating from restaurants still occur. Recently, clusters which originate in the family have also occurred. Here, specific causes of clusters are analyzed and a countermeasure recommendation is reported. Method: A person must take off his mask while eating and drinking. If one is alone, not to putting the mask back on is fine. However, if others are present, the possibility of infection by airborne droplets during conversation cannot be dismissed. However, when eating and drinking in a group, most people do not put their mask back on. This is clearly a “rule violation.” Consequently, actual conditions are shown using t-WFC, an analysis of COVID-19 clusters is carried out, and a countermeasure is proposed. Results: There is no guarantee that the others with whom one is eating and drinking are not infected. The person may be in the incubation period, or being a carrier without symptoms. Consequently, when not eating alone, one should wear a mask. In addition, efficacy of a mask varies by type. More effective masks should be used. There are some rules in time for meal together, such as social distancing, the number of participants, etc. However, effective mask use can prevent infection while eating and drinking. Conclusion: The misconception that the eating and drinking members do not have virus should be corrected.
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Among emerging pollutants, potential effects coming from their contemporary presence with nanoparticles (NPs) in the environmentare of great concern. The co-existence of NPs of classical and emerging pollutants into the aquatic system potentially modifies their interaction with the biota. Within classical pollutants, Cd and Cd-compounds have been classified as human carcinogens by the International Agency for Research on Cancer (IARC), representing an environmental problem that also involves human health. Among cellular cadmium effects, the most important seem to be cadmium interaction with DNA repair mechanisms, generation of reactive oxygen species and induction of apoptosis. The present study aimed to investigateif cellular mechanisms of cadmium-induced toxicity resulted affected by the interaction between organic and inorganic nanoparticles. Cellular responses were investigated in cadmium-contaminated marine waters after exposure of both organic and inorganic NPs: two forms of commercial nano-TitO2 and carbon black (CB)-derived hydrophilic NPs. Portions of the marine mussel Mytilusgalloprovincialis gill tissue were exposed to CdCl2 in presence of selected NPs to simulate the interactions between cells and xenobiotics. DNA primary damage was evaluated by the alkaline version of Comet assay; chromosomal damage and cell proliferation were assessed by Cytome assay; apoptosis was evaluated by Diffusion assay. Moreover, TEM in cell was planned to check the actual internalization of NPs, in order to verify that the potential genotoxic effects induced by NPs were paralleled by their cellular uptake. An induction of apoptosis in gill cells from CdCl2 treated biopsies was observed while the level of apoptotic cells exerted by CdCl2 was recovered to the control level in gill biopsies co-treated with CdCl2 and NPs (both organic and inorganic). In terms of DNA primary damage the selected NPs did not exert genotoxicity when tested alone, and only the inorganic ones were able to reduce the DNA damage level exerted by cadmium treatment even though not to the control level. These results provided informations for the innovative remediation approaches aimed to promote the use of nanoparticles (NPs) to clean metal-contaminated waters for human and environmental health protection.
Patrizia Guidi defended her PhD thesis in 2011 at University of Pisa (Italy). She is a biologist, and, at the moment, she is Assistant Professor of Applied Biology at the University of Pisa. Her research is focusing on cellular responses and genotoxic effects of nanomaterials and xenobiotics. She has published 22 papers in reputed journals and many abstracts presented at national and international congresses.
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Objectives: Currently published papers and clinical guidelines regarding the effects of tocilizumab in severe and critical COVID-19 are contradictory. The aim of this meta-analysis was to combine the results of clinical studies of different designs to investigate the efficacy and safety of tocilizumab in severely-to-critically ill COVID-19 patients. Methods: A systematic search was performed in PubMed, Embase, CENTRAL, ClinicalTrials.gov, Scopus, and preprint servers up to 26 December 2020. Since a substantial heterogeneity was expected, a random-effects model was applied to calculate the pooled effect size (ES) and 95% confidence interval (CI) for each study outcome. Results: Forty-five comparative studies involving 13,189 patients and 28 single-arm studies involving 1,770 patients were analyzed. The risk of mortality (RR of 0.76 [95%CI 0.65 to 0.89], P < 0.01) and intubation (RR of 0.48 [95%CI 0.24 to 0.97], P = 0.04) were lower in tocilizumab patients compared with controls. We did not find any significant difference in secondary infections, length of hospital stay, hospital discharge before day 14, and ICU admission between groups. Conclusion: Tocilizumab can improve clinical outcomes and reduce mortality rates in severe to critical COVID-19 patients. Large-scale randomized controlled trials are still required to improve the statistical power of meta-analysis.
Soheila Rezaei is Pharm.D and Ph.D. candidate of Pharmacoeconomics and pharma management, Pharmacy Faculty of Shahid Beheshti Medical University, Tehran, Iran. She interested in some topics of public health that related to Health Economics and Outcome Research, Medication adherence, and Pharmacoeconomics evaluation study. She has been in charge of execution of several scientific studies and cost-effectiveness analysis projects for multinational company offices in Iran like Sanofi Aventis, Roche, and Novo Nordisk. Also, she is finalizing her Ph.D. thesis entitled “Development and empirical analysis of a conceptual model of cost-related medication nonadherence inIranian elderly patients”.Her ambition and desire to everyday learning and quickly growing ishighly appreciated by her colleagues and academic professors. She is an exemplary wife and mother, too.
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Objectives: Thousands of proteins undergo arginine methylation, a widespread post-translational modification catalyzed by several protein arginine methyltransferases (PRMTs). However, global understanding of their molecular mechanisms and biological functions is limited due to the lack of a complete picture of the catalytic network for each PRMT and the absence of reliable antibodies and mechanically well-defined ‘erasers’ and ‘readers’. Here, we systematically identified interacting proteins for all human PRMTs and hope to contribute to arginine methylation field and help the study of related biological processes. Results: Using a sensitive BioID technology and mass spectrometry, we systematically characterized the interactome and the substrate specificity of all known human PRMTs. The results demonstrated significant overlapping of interactomes of human PRMTs with the known methylarginine-containing proteins. Different PRMTs are functionally redundant with a high degree of overlap in their substrates and high similarities between their putative methylation motifs. After bioinformatics analysis and experimental validation, we revealed that RNA-binding proteins (RBPs) involved in regulating RNA splicing and translation are highly enriched in PRMT interactomes and undergo extensive arginine methylation, indicating their importance in regulating RNA metabolism. Applying RNA-seq and Ribo-seq, we demonstrated that the inhibition of PRMTs leads to global alteration of splicing and translation inhibition.In particular, ribosomal proteins are extensively modified with methylarginine, and mutations in their methylation sites suppress ribosome assembly, translation, and eventually cell growth, indicating arginine methylation of ribosomal proteins is critical to ribosomal assembly. Conclusions: This study provides new insights into biological functions of PRMTs and links individual PRMTs to their arginine methylation events, revealing critical functions of arginine methylation in regulating RNA splicing and translation. We hope that the new findings and the data analysis methods in this study will be of broad interest to investigators in the fields of protein modification and RNA biology. Graphical Abstract: Arginine methylation is highly involved in RNA splicing and translation. The putative PRMT substrates were subjected to protein-protein interaction analysis from the STRING database (v10.5, the minimum required interaction score was set to high confidence at 0.7), the resulting networks were clustered by MCODE in Cytoscape software. The orange nodes indicate functions related to translation and the cyan nodes indicate functional enrichment in RNA processing.
Dr. Wei,Huan-Huan is an assistant professor at PICB, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS). She obtained her Ph.D. degree at South China Institute of Botany, CAS. After graduation, she worked at FuDan University as a lecturer where her research focuses on the molecular mechanisms of macrolidesin inhibiting pancreatic and breast cancers. During 2014-2016, She worked in Zefeng Wang’s lab as a visiting scholar in University of North Carolina at Chapel Hill andlater she joined Zefeng Wang’s group at PICB in 2016. Her recent study interest focuses on the mechanisms and regulation of aberrant alternative splicing in cancers as well as the mechanisms and functions of arginine methylation on RNA splicing factors.
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Introduction: Beta thalassemia major is the commonest inherited hematological disorder worldwide which needs lifelong sufficient supportive management. Hematopoietic stem Cell transplantation (HSCT) is the only curative treatment available till now. Aim: To evaluate the outcome of children who underwent allogenic hematopoietic stem Cell transplantation as a curative approach for Thalassemia Major. Settings: Queen Rania AL- Abdullah children Hospital (QRCH). Methods: A retrospective review of the medical files was conducted for all children (< 15 years) who had thalassemia major and received HSCT between January, 2010 and January, 2019. The following variables were studied for all patients: age, gender, Pesaro classifications, the count of infused raw bone marrow stem cell (CD34), engraftment time, outcome and complications. Results: A total of 34 children were transplanted for thalassemia major, at an average of 4 cases per year. All underwent allogenic raw bone marrow transplantation from matched related donors. Thirteen patients (38.2%) were males and twenty one (61.2%) were females. The age ranged between 2 and 15 years, with a median age of 6.5 years. According to Pesaro classification, 31 patients were class 2 (91.2%) and 3 patients were class 3(8.8%) while no single case met the crieteria for class 1 Pesaro classification. The median CD34 count was 3.5 million /Kg of recipient weight (range, 1.5*106-7*106 /kg). The median time for neutrophil engraftment was 15.5 days. At a median follow up of 5 years (range 1- 9.5), 33 patients were alive. One patient died before 100 days post transplantation due to grade IV acute gastrointestinal Graft Versus Host Disease (GVHD). Three patients had secondary graft failure (8.8%). Six patients (17.5 %) developed mild grade 1-2 skin GVHD while another patient developed hemorrhagic cystitis due to BK virus and cytomegalovirus (CMV) which reactivated simultaneously, and was successfully managed . Conclusion: The outlook for Thalassemia major has dramatically changed after HSCT, with a considerable success in Jordan and results comparable to international data.
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Background: Coxiella burnetii is the causative agent of Q fever which is a highly infectious zoonotic disease. C. burnetii has become one of the most important causes of abortion in livestock, which can lead to widespread abortions in these animals. There are very limited studies on the prevalence of C. burnetii infection in cases of animal abortion in Iran. The aim of this study was to investigate the occurrence of C. burnetii in ruminant abortion samples in Iran. Methods: Abortion samples from cattle, sheep and goats were collected from different parts of Iran and were tested using Real-time PCR targeting the IS1111 element of C. burnetii. Results: In this study, 36 samples (24.7%) of the 146 collected samples were positive for C. burnetii. The prevalence of C. burnetii was 21.3% (20 of 94 samples) in sheep samples. Also, 10 of 46 cattle samples (21.7%) were positive. All six goat abortion samples were positive for C. burnetii. Conclusions: The findings of the study demonstrate that C. burnetii plays an important role in domestic ruminant abortions in Iran, suggesting that more attention should be paid to the role of C. burnetii in domestic animal abortions by veterinary organizations. The risk of transmitting the infection to humans due to abortion of animals should also be considered.
Dr. Saber Esmaeili is an assistant professor and Researcher in Medical Microbiology at Pasteur Institute of Iran. Her primary research interest is bacterial emerging and re-emerging pathogens, including Coxiella burnetii, Bartonella, Francisella, Rickettsia and Yersinia pestis.
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Wastewater-based epidemiology (WBE) is a concept in which wastewater can be utilized as an indicator to understand the presence and scale of infection. WBE can provide an alarming and early indication about the presence of COVID-19 infected individuals in a city, town, and even in a housing complex. Current data on SARS-CoV-2 and other viruses suggest that wastewater-based epidemiology is a viable addition to the assessment and mitigation of viral outbreaks.The presence of SARS-CoV-2 RNA in wastewater may predict COVID-19 occurrence qualitatively and quantitatively. Few articles reported a correlation of SARS-CoV-2 RNA concentration in wastewater with the number of COVID-19 cases, whereas few reported higher prediction by wastewater surveillance than confirmed cases. The application of WBE is still in a preliminary stage but has the potential to indicate an early sign of transmission.The commonly adopted disinfection technologies in inactivating SARS-CoV-2 in municipal and hospital wastewater is required to reduce the risk associated with municipal and hospital wastewater. Applicability of WBE in terms of detection limit by several PCR-based assays and they observed presence of SARS-CoV-2 in wastewater even when the number of cases per 100,000 was below 1. Therefore, the monitoring through WBE can provide an early indication of emergence of COVID-19. It was observed 10 out of 66 wastewater samples as positive collected from toilets, showers, and wash.
Associate Professor at Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences. Over 30 years of research and teaching in BS, MS, PhD courses. Over 100 research project and about 600 published papers.
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Channelopathy constitute significant proportion of SCD worldwide ( around 10% or 370000 death annually). Besides LQTS, the channelopathies include Brugada syndrome (BrS), short QT syndrome,Early Repolarization Syndrome(ERS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and congenital sick sinus syndrome. It was constituting a mysterious group of disease until the second half of the last century when Anton Jervell and Fred Lange-Nielsen described Jervell Lange-Nielsen syndrome in 1957.It was late until 1995 where genetic characterization commenced. Later on the massive genetic information obtained in the field with discovery of genetic heterogeneity and allelic heterogeneity were all part of our new understanding and clues to solve the historical conundrum of channelopathies. In this presentation, we review the genetic basis of sudden cardiac death with a focus on the current knowledge on the genetics of the primary electric disorders caused primarily by mutations in genes encoding ion channels. Diving deep into the genetic details of those syndromes enable us to improve our knowledge and decode the pathophysiology of those malignant arrhythmias. The ultimate ambition is prevention of channelopathy based sudden cardiac death and associated disorders in human.
Professor Abdullah Alabdulgader, MD, DCH(I), DCH(Edinb), MRCP(UK), ABP, FRCP(UK) was born in Al -Khobar and raised in Al-Hasa, in the eastern part of Saudi Arabia. Al-Hasa is in the middle of ancient wisdom with cultural and religious sobriety, while being embraced in marvellous harmony with the gigantic oil industry. His genetic lineage extends to the Al-Ansar tribe where, over 40 generations ago, Abu AyubAlansari was one of the elite partners of prophet Muhammad. Professor Alabdulgader graduated from the college of medicine and medical sciences, King Faisal University, in 1991. Immediately, after graduation, he was involved in extensive medical training, cascaded at different levels of specialties, until 1997 where he was certified with five medical degrees. This qualified him to double major specialty in paediatrics and adolescent medicine and subspecialty in paediatric cardiology with awards from Saudi Arabia, Ireland and the United Kingdom. He excelled to achieve a record achievement in becoming a member of the Royal Colleges of Physicians (UK), having completed all examinations and requirements in just 12 months and becoming an MRCP(UK) holder at the age of 27. Soon afterward he established he first foundation for congenital heart services in eastern Saudi Arabia. In addition to optimizing the organization of clinical services, research was one of his paramount priorities. Professor Alabdulgader has long been fascinated by the epidemiology of cardiac dysmorphology in humans. He initiated examination of the incidence and demographic characteristics for congenital heart disease for the first time in his part of the world. This scientific step heralded the onset of one of the major scientific projects in human history – concerned with discovering the environmental and genetic risk factors of congenital heart diseases in an attempt to discover the mysterious secrets of human heart dysmorphogenesis, with the ultimate aim of overcoming the disease in human species. In 2001, Professor Alabdulgader was granted a special governmental scholarship to further sub-specialize in cardiac electrophysiology and electrical rhythm devices. This. study was undertaken in Edmonton, Alberta, Canada. During this time, he was able to describe, for the first time in medical literature, unique congenital anomalies, in native Canadian new-borns, from Calgary University hospital. He is well known for founding the Prince Sultan Cardiac Center, in Al-Hasa, Saudi Arabia (PSCCH) after a generous donation from the late crown prince of the country HRH Prince Sultan bin Abdulaziz. PSCCH, today, is one of the leading tertiary care cardiac centersin the middle east and the world. Professor Alabdulgader’s holistic universal scope in science and the universe led him to establish the reputable King of Organs Congress for Advanced Cardiac Sciences, where the wisdom dictates perceiving the human heart as a souvenir of the soul and a cradle of the mind and wisdom, with extensive and delicate symphony resonating to higher energetic levels of collective consciousness. Critical conceptual faith and reasoning behind the King of Organs establishment was to rescue humanity from the historical myths with absent scientific insight, such as the great cholesterol myth. Professor Alabdulgader, as the congress founder and president, and the late professor Paul Rosch, as his congress deputy, devoted a full day of scientific debate to expose the cholesterol myth in four 12 consecutive international conferences (2008, 2010, 2012 and 2019). In other work, Professor Alabdulgader collaborated with HeartMath Institute, California, USA, where he was able to establish a special detection system to record the planetary Schumann frequencies. He was awarded the world gold medal from WOSCO (Great Britain-2012) for establishing unique direction in astrobiology and cardiac sciences exploring the human heart rate variability orchestration with Schumann resonances and solar winds. In the same year he was awarded the Diploma of honour from the International Committee on geological and environmental change (GEOCHANGE), Munich, Germany. In 2018, he led a scientific team from HeartMath Institute, NASA, along with a reputable European scientist, in the longest human record synchronizing human heart rate variability with Schumann resonances, solar winds and cosmic rays. This achievement was published in Nature scientific reports in February 2018. Nowadays, Professor Alabdulgader is leading a number of international projects concerned with investigating the role of the very low frequency band of the heart rate variability in inflammation and systemic hypertension to treat systemic hypertension without medications. The Saudi Homocysteine Atherosclerosis and Cancer Trial (SAHACT) utilizes cellular pathways with simple nutrients to combat atherosclerosis and cancer in human, and other projects. In the clinical arena he is a senior interventional congenital cardiologist and electrophysiologist performing ablation interventions with radiofrequency as well as cryoablation technologies utilizing cardiac electrical mapping to cure cardiac arrhythmias. Professor Alabdulgader is a scientific board member and editorial board member of many international organizations and journals in the USA, UK, Germany, Switzerland, China, India and other countries. He has received many acknowledging letters and honouring events and gifts from King Salman, Princes, and world authorities. At the moment, he is the senior scientist and chief physician in PSCCH and the leader of the research and biostatistics services, preparing for the next King of Organs congress with higher consciousness for the better future of humankind.
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Tetracycline (TC) is one of the most commonly used broad-spectrum antibiotics to treat bacterial infection. TC antibiotics enter into the environment because of partial metabolism in humans and animals, thereby increasing environmental toxicity. Therefore, it is highly needed to treat TC antibiotics from the water system. In this aspect, the present work focus on the synthesis of metals incorporated bismuth-oxy-iodide (M-BiOI) based photocatalyst materials by varying metal and amount of metals. Figure. 1 shows the schematic representation of the M-BiOI based photocatalyst material. The incorporation of the metals within the BiOI aided advantages that decrease the band gap value. Interestingly, incorporation of the metals within the BiOI increases the oxygen defects, thereby high photo-degradation ability. The prepared M-BiOI based photocatalyst efficiently degrade antibiotics from water. The photocatalytic activity against bacteria of the M-BiOI was also determined. The data suggested that the prepared M-BiOI based photocatalyst materials efficiently inhibit bacterial strains. Therefore, the prepared M-BiOI based photocatalyst materials shows potential ability for efficient degradation of antibiotics compounds as well as bacteria.
Dr. Neetu Talreja is working as a Researcher at, Department of Materials Engineering, Faculty of Engineering, University of Concepcion, Concepcion 4070409, Chile. She has completed Ph.D. in Chemistry from the collaboration of the Indian Institute of Technology, Kanpur, India, and Banasthali University, Banasthali, India. Before joined the University of Concepcion, Concepcion, Chile, She worked as a Researcher at the University of La Serena, Chile, Gachon University, South Korea, and Department of Chemical Engineering, Beijing University of Chemical Technology, Beijing, China. Dr. Neetu's research focuses mainly on interdisciplinary science involving nanomaterials and chemical sciences such as synthesis, characterization of nanomaterials mainly two-dimensional nanomaterials, and polymeric composite-based materials for energy and environmental applications. The leading field of science that is relevant to her area of interest consists of nanotechnology, nano-bioscience, energy, and environmental remediation applications of polymeric composite/nanotechnology. Dr. Neetu has wide experience of handling various characterization tools such as scanning electron microscopy, transmission electron microscopy, x-ray photoelectron spectroscopy, Zeta-sizer to investigate zeta potentials, and particle size/agglomeration behavior of nanoparticles/carbon-based materials in liquid media, thermo-gravimetric analysis, x-ray diffraction (XRD), surface area analyzer, Fourier transformed spectroscopy and atomic field microscopy (AFM) for the characterization of different materials.
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The last few decades have shown that public health is directly associated with environmental health. Environmental fitness depends on the rate of atmospheric revival. Air pollution including particulate and gaseous emission is one of the primary causes of several human health hazards, thus hindering the sustainability and biodiversity of our mother planet. The polluted air pathway can be even more dangerous medium for the transmission of several deadly and infectious health syndromes. Presently the entire world is suffering from the global fever of novel coronavirus. There are huge scientific evidences till date, which proves that such novel virus or virus of its kind can easily spread through several indoor and outdoor atmospheric routes in form of the aerosol molecule. Moreover, it is quite essential to demarcate the sources and root causes of such atmospheric hazards, leading to potential threats in form of such emerging unknown airborne disease transmission. The research societies have already made us aware of the combined effects of such biochemical hazards leading to casualties. This might lead to chronic as well as acute health syndrome, thus unbalancing the equilibrium of several life forms and our ecology. Prolonged exposure to such airborne virus adhered to air particulates might impose severe alert even during the post-pandemic situation. So it is high time to deal with the feasible preventive measures over hazardous air pollution and associated atmospheric viral transfer. Some of the best possible and available chemical engineered processes like the scrubbing technologies in the wet and dry state can operate efficiently with an associated low-cost disinfection technology to combat the global problem. Such green-engineered-technologies will work quite efficiently even during the pre, post-pandemic situation for complete removal of target materials. These possible suggestions help in proper environmental surveillance thus monitoring the further spread of air pollutants and biohazards globally.
Subhrajit Mukherjee is presently working as a Doctoral Research Scholar (SRF) at the Environmental or Industrial Pollution Control Laboratory at the Department of Chemical Engineering in IIT Kharagpur. He has previously completed his M. Tech. from the same department at the multi-phase fluid flow laboratory in IIT Kharagpur, where he was mainly involved in the specific research related to process intensification and two-phase flow in millichannels. His present research is mainly associated with air pollution control cum environmental health, management of hazardous materials, advancement in scrubbing technologies, recycling-cum-reutilization of wastes at low cost, etc. He has published several remarkable research outputs in form of conference papers as well as peer-reviewed journals in the above specific fields. He acts as a life member and life associate member of prestigious academic bodies like the Indian Institute of Chemical Engineers (IICHE), International Environment Forum (IEF), Institution of Engineers (IEI), International Association of Engineers (IAEng), and many more.
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In the prevailing coronavirus disease-2019 (COVID) times, scientists are eager to develop vaccine against COVID-19, and careful measures are being taken to develop an effective drug. Meanwhile, several antiviral compounds have been repurposed for the COVID-19 treatment, and drug repurposing has yielded satisfactory results. In the meantime, NO is also under clinical trials to find its potentiality as anticoronavirus. This work aims to describe the therapeutic potential of nitric oxide (NO) for the treatment of deadly (COVID-19). As, the cytokine storm has been mainly found concerned with the uncontrolled deaths in the COVID-19 apocalyptic times. The co-morbid deaths along with other fatalities have urged medicinal researchers to seek for emergency drugs/medicines to fight this dreadful disease. Nitric oxide therapy is one of the prominent therapies being eyed as the efficient option for treating coronavirus infected persons. Therefore, keeping in view the natural involvement of NO in immune system, antiviral (anticoronaviral in special) implications and the significance of NO in mitigating the COVID-19 associated symptomatic complications, this work addresses the noble treatment of nCOVID using NO as a drug. So, the profound antiviral effects of NO against coronavirus, and also the role it plays in relieving symptomatic severity of COVID-19 are supportive of the fact to declare NO as a therapeutic option for this disease.
Dr Jan Mohammad Mir is currently working as an Asst. Professor at the Islamic University of Science and technology, Awantipora-J&K. He bagged his Ph.D. from R.D. University, Jabalpur in 2015 and is about to complete his D.Sc. degree from the same university. His postdoctoral research mainly involves the molecular modeling and medicinal implications of metal based gasotransmitters. Currently, he is seeking the role of NO, CO and H2S in minimizing the COVID-19 associated severity. He has been a good academician and a researcher. He guided so many research projects entailed with M.Phil. and M.Sc. students. As a young researcher his scientific contributions have got more than 400 citations till now. As per the available details, he has published more than fifty research papers of current scientific temper in various reputed journals covering most of the world famous publishers. He has complied more than seven books and several book chapters till now. Dr Mir is currently serving as editor as well as reviewer for several esteemed journals.
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Introduction: Usutu Virus (USUV) is a vector-borne flavivirus within the family of Flaviviridae; its reservoirs and vectors are birds and mosquitoes,respectively. Methods: At first, electronic databases were searched with a date range from 2000 to 2018 to find the Culexspecies that transmit the disease and then fordetermining the diversity of those, mosquito larvae were collected from six places in three main environmental categories using the dippingtechnique. Results: In total, 1369 specimens belonging to 10 different species were collected and identified, as follows: Cx. hortensisFicalbi, Cx. laticinctusEdwards,Cx. mimeticusNoe, Cx. perxigusTheobald, Cx. pipiensLinnaeus, Cx. modestusFicalbi, Cx. sinaiticusKirkpatrick, Cx. theileriTheobald Cx.torrentiumMartini and Cx. tritaeniorhynchusGiles. Four species involved as vectors of USUV in other countries are printed in bold. Cx.pipiens, as the main vector was the most frequent species in rural areas, share its larval habitats with Cx. torrentium(similarity > 0.9) and reached its peak inAugust. Overall, in the present study, there was a significant positive relationship between mean temperatures and abundance of mosquitoes (r =0.75, P = 0.005). Conclusion: In the present study, some species involved as main vectors of USUV in other countries and their ecological features were recorded. Based on these results, the possibility of the emergence of USUV in Iran exists.
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Background: Diabetes is a huge growing problem, and causes high and escalating costs to the society. Self- care practice for adults with diabetes is not well addressed in sub-Saharan Africa including Ethiopia. To prevent serious morbidity and mortality, diabetes treatment requires commitment to demanding self-care practice. The aim of this study was to assess self- care practices and its associated factors among adults with diabetes in Dire Dawa public hospitals of EasternEthiopia. Methods: Cross-sectional study was conducted among 513 adults with diabetes. The study participants were selected through systematic random sampling. Data was collected from February 1st to March 1st, 2018.Patients were interviewed using a structured questionnaire. Data were entered into Epi-data version 3.3.1 and exported to SPSS version 22.0 for analysis. Bivariable and multivariable logistic regression with crude and adjusted odds ratios along with the 95% confidence interval was computed and interpreted accordingly. A P-value of <0.05 was considered to declare a result as statistically significant. Result: The result of the study showed that 55.9 %, (95% CI: 51.4, 60.3) of participants had good self-care practices. Good self-care practice was associated with having family support, treatment satisfaction, diabetes education, having glucometer, higher educational status, duration of the disease, high economic status and having good knowledge. There were statistical association between good diabetes knowledge (AOR= 2.14 , 95% CI :1.37, 3.35), family support system (AOR= 2.69, 95% CI:1.56, 4.62), treatment satisfaction (AOR= 2.07, 95% CI:1.18, 3.62), diabetes education (AOR= 2.21, 95% CI: 1.35, 3.63), high economic status (AOR= 1.89, 95% CI: 1.01, 3.48), having glucometer,(AOR=2.69, 95% CI:1.57, 4.63),higher educational status (AOR= 2.68 , 95% CI: 1.31, 5.49), and duration of disease greater than 10 years AOR=2.70, 95% CI: 1.17, 6.26) with good self-care practice. Conclusion: In this study a substantial number of the patients had poor self-care practices especially dietary practice and self-monitoring of blood glucose which have critical roles in controlling diabetes. Provision of diabetes self-care education and counseling especially on importance of self-monitoring of blood glucose, and dietary practice should be considered by responsible bodies.
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Novel coronavirus (SARS-CoV-2) emerged in Wuhan, China, and it most commonly presents with respiratory symptoms ranging from cough, low-grade fever to severe pneumonia. Neurological complications of COVID-19 remain largely unfamiliar and sometimes the unique initial presenting complaint of COVID-19. We reported the first unique presentation of SARS—CoV-2 virus in a 21-years-old medical student, who presented with initial signs and symptoms of meningitis and later on developed respiratory symptoms on the second day of admission. An extensive work-up was done to evaluate the cause of meningitis, the results of which were unremarkable (Table 1). As per hospital protocol and based on respiratory symptoms, a nasopharyngeal swab for SARS-CoV-2 was sent, the result of which came out positive. He was labeled as a case of meningitis secondary to probably SARS-CoV-2 infection, as no other causative factor was found. His condition deteriorated and unfortunately, he died because of multi-organ failure. Conclusion: The SARS-CoV-2 virus can cause neurological manifestations by various proposed mechanisms. It can spread to the braindirectly through angiotensin-converting enzyme receptors 2 or it can affect the brain through hematogenous spread or neuronal pathway. As these neurological manifestations are fatal, a physician should keep in mind all these manifestations, while encountering patients, especially during this pandemic. Early diagnosis can have a good outcome for the patients as well as we can prevent the vertical spread of this virus by taking precautionary measures.
Muhammad Hanif is an international medical graduate from Pakistan. He is currently working as an internal medicine resident at Hayatabad Medical complex, Peshawar, Pakistan. He is ECFMG certified.
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Objective: Walnuts are widely consumed nut by men in Nigeria and it has been connected to improving male reproductive health. This study evaluated the effect of African walnut on sperm parameters and testicular architecture of nicotine (NIC)-induced reproductive toxicity in male Wistar rats. Methods: Wistar rats were randomly assigned into four groups, that is, GN0 (1 ml/day normal saline and normal rat chow), GN1 (1 ml/day NIC and normal rat chow), and GN1W6 and GN1W12 (1 ml/day of NIC daily fed with 6% and 12% walnut-rich feed), respectively. This continued for 28 days. The animals were euthanized and their sperm was collected and its parameters were analyzed. The testis was harvested and prepared for histological examination. Results: NIC significantly reduced sperm motility (P = 0.0006) and sperm count (P = 0.0001), induced mild apoptosis of Leydig cells and caused moderate spermatogenic arrest in GN1. However, walnut-supplemented diet significantly increased the NIC-induced reduction in sperm motility (P = 0.04) and sperm count (P = 0.0001) and its consumption was effective in attenuating testicular damage caused by NIC administration in GN1W6 and GN1W12. Sperm parameters (Mean ± SD) of the positive control, negative control, 6% Walnut and 12% Walnut respectively. Conclusion: African walnut could exert therapeutic effect in the reduction of the adverse effect of NIC on the sperm motility, sperm count, and testicular architecture. It is worthwhile to consider it as a useful and affordable supplement to be added to the diet of males with infertility problems.
David C.IkwukaPh.D is a leading researcher in Biomedicine known for his leadership skills and research potential. He is currently a Faculty member in the Department of Physiology, NnamdiAzikiwe University, Nnewi Campus, Nigeria where he teaches and mentors research of medical and paramedical students in Physiology, and is currently pursuing a Ph.D in Physiology at the Department of Physiology, University of Nigeria Enugu Campus, Nigeria. His research interest includes Reproductive Physiology, Blood Physiology, Immunology and Environmental Physiology. He has authored several publications, invited and peer-reviewed several manuscripts for high impacted Journals and seats as editorial board member for a few Journals.
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Objectives: Summary and discussion of a systematic review and meta-analysis on efficacy of low-level laser therapy (LLLT) for shoulder tendinopathy. Results: Positive effects reported in 11 of 17 (73%) studies. Six studies reported no significant effects but 4 were found to have inadequate dosage. Eleven of 15 studies addressing pain relief favored LLLT over no treatment, placebo, or other modalities. When only studies with adequate dosage based on World Association for PhotobiomoduLation Therapy (WALT) recommendations were used, 10 of 11 (90%) studies reported significant pain reduction. Discussion: Photobiomodulation (PBM) therapy entails the therapeutic use of light energy to affectphotophysical and photochemical mechanisms of endogenous chromophores. LLLT is one form of PBM used to inhibit pain and inflammation or stimulate wound healing and tissue regeneration. PBM therapy can be used as a monotherapy or as an adjunct with other interventions to reduce pain associated with shoulder tendinopathies.To obtain optimal outcomes, clinicians mustprovide adequate dosage energy in joules (J) to the tissue. Distance to the target tissue, pigmentation, makeup of tissue content, and size of the total tissue area (cm2) treated affects dosing. Dosage is related to the wavelength of light, number of diodes for each energy source, irradiation area point size (cm2) of the aperture, and the calibration of the PBM device. Power output is affected by the peak power (W), pulse rate or frequency (Hz), pulse width (s), and duty cycle (%) while energy (J) is affected by power (W) multiplied by treatment time (s). Dosage should be based onWALT minimum recommendations of an energy density of 2 to 4 J/cm2 or 2 to 8J of total energy. Conclusion: PBM can be an effective tool for treating shoulder tendinopathies if clinicians understand tissue considerations, unit settings, and follow WALT recommended dosage guidelines.
Kristen (Kris) Agenais a faculty member in the Health Promotion and Exercise Science department and athletic trainer at Luther College in Decorah, Iowa, USA. She completed a Bachelor of Arts degree in Biologyat Simpson College in 1995, a Master of Science degree in Exercise Science at the University of Iowa in 1997 and is set to complete the Doctor of Athletic Training degreefrom A.T. Still University in June 2021. Kris holds certifications as a BOC Certified Athletic Trainer (ATC), NSCA Certified Strength and Conditioning Specialist (CSCS), NASM Corrective Exercise Specialist (CES), as well as FMS Functional Movement Screen Level-2 (FMS-2) and Functional Capacity Screen (FCS) certifications. She is a member of the National Athletic Trainers’ Association and National Strength and Conditioning Association, an American Red Cross First Aid, CPR and AED Instructor and is a recipient of the American Red Cross National Lifesaving Award of Merit.
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The entire healthcare system has been thrust towards a more virtual delivery model, including site-less virtual clinical trial recruitment. In this case study, a five-stage process is illustrated in which a 1,000-patient virtual clinical trial was completed in just seven months, and at a cost which was 30% lower than traditional site based recruitment. Participants were located, educated and navigated through a successful multi-step virtual clinical trial for an at home colon screening test. Overall, the trial achieved a timeline from the first participant to final analysis in about six months, followed by dataset review and analysis completed in just 5 days.
Alex Hilderbrand is Vice President of Patient Activation at 83bar, Inc. He is a senior marketing strategistfor clinical trials, diagnostics, and medical devices. He has helped shape demand generation, patient navigation, engagement and retention capabilities into campaigns that generate ROI and accelerate patient recruitment. Mark Stinson is Vice President at 83bar Inc. His work includes market research, customer journeys, product branding, and marketing strategy for health, science, and technology products.He is the author ofhealthcare business books and published journal articles. Mark has been included in the PharmaVoice 100 Most Inspiring People in the Life-Sciences Industry.
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The entire healthcare system has been thrust towards a more virtual delivery model, including site-less virtual clinical trial recruitment. In this case study, a five-stage process is illustrated in which a 1,000-patient virtual clinical trial was completed in just seven months, and at a cost which was 30% lower than traditional site- based recruitment. Participants were located, educated and navigated through a successful multi-step virtual clinical trial for an at home colon screening test. Overall, the trial achieved a timeline from the first participant to final analysis in about six months, followed by dataset review and analysis completed in just 5 days.
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Abstract should give clear indication of the objectives, scope, results, methods used, and conclusion of your work. One figure and one table can be included in your results and discussions. Coronavirus disease 2019 (COVID-19) was first identified at the hand of 2019 has a cluster of pneumonia cases in Wuhan, China. By February 2020, the virus quickly spread, becoming a global pandemic. The spectrum of a symptomatic infection severity can range from mild, severe, and critical disease. Many correlated comorbidities where established, including smoking, socioeconomic background, gender (Male prevalence), hypertension, obesity, cardiovascular disease, chronic lung disease, diabetes mellitus, cancer, and chronic kidney disease. In an extensive literature search, post-COVID-19 housing staphylococcus aureus pneumonia with pneumothorax has not been recorded. We present a case about a 62-year old male who presented with symptoms of COVID-19 with many underlying comorbidities, including hypertension and hyperlipidemia. He was on ventilator support during his first week in the hospital and then received supplemental oxygenation as he recovered from his COVID-19 pneumonia. Nearly a month and a half after his initial presentation he quickly decompensated and was started on supplemental oxygen and necessary treatments. It was then, with aid of lab work and imaging, daddy we determined that he had developed necrotizing Staphylococcus aureus pneumonia with pneumothorax. He was adequately treated, and once he was stable, he was discharged home and was told to continue his therapy.
Lidiya Didenko is a fourth-year Global MD medical student from the American University of Antigua and is planning on pursuing a career in Physical Medicine & Rehabilitation. She is currently completing the Core Clerkship Program at Florida International University Herbert Wertheim College of Medicine. She is fluent in three languages, English, Spanish, and Russian.
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One of the key management lessons of the health and economic impact of COVID-19 pandemic is that agility is a critical success factor for organizations in a pandemic and post pandemic business environment. Organizations recognize that in this rapidly changing technology environment, the desire to be more competitive and increase profit margins has accelerated the need to attract, recruit, and retain a nimbler, more flexible, more adaptive, and digital-centric generational workforce. The heightened search for the 21st Century workforce has led to business leaders, Human resource managers, and talent management professionals to focus on Generation Z. Gen Z is the youngest and newest entrants into the workforce. However, the confusion about their characteristics, work values, and reward preferences hinders efforts to attract, recruit, and retain this generational cohort into public sector organizations. Accordingly, this study investigates effective reward strategies for attracting, recruiting, and retaining the youngest generational workforce into public sector organizations. I used evidence-based research approach and aggregative systematic review as the study methodology. The evidence curated from 32 studies reveals gender to be a moderating factor for how important specific work values are to Generation Z. The preponderance of evidence shows the intrinsic and extrinsic rewardspreferences of Gen Z are reliable predictors of their attraction to, and retention by public sector organizations. Additionally,effective management of person-organization fit and adaptive organizational culture emerge as substantial mediating factors for attracting, recruiting, and retaining members of the Generation Z cohort.
Nana Amma Acheampong is an educator who currently works as a Management consultant for MKU4 Express Courier & Logistics. After receiving the first part of her tertiary education in Ghana, West Africa, Mrs. Acheampong worked as an Administrative Liaison Officer at the Office of the President, Ghana. Also, she managed administrative and communications affairs for the Economic Community of West African States’ (ECOWAS) offices in Guinea Bissau and Cote D’Ivoire. In 2019, Mrs. Acheampong graduated from the University of Maryland Global Campus with a doctorate degree in Business Administration. She aims to pursue a social entrepreneurship path by providing consulting services in markets where legislative frameworks and regulatory guidelines for equal opportunity employment is lacking. From 2018 to present, Nana Acheampong has contributed, in an advisory capacity role to Rural Heights Foundation (a non-profit in Ghana, West Africa) as an advisor to Rural Heights Teacher Capacity Development Program (iTeach).
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The separation of concerns as a conceptual paradigm aims to manage the complexity of the software systems by dividing them into different concerns and aspects. The benefits of this paradigm such as adaptability, reusability and maintenance, have been key drivers of its adoption and usability, particularly in healthcare systems. Developing a system with adaptive, flexible and maintainable architecture requires modularity because we must be able to design a flexible system that allows us to make decisions based on context of patients. In the emerging healthcare architectures, the fundamental characteristic of healthcare applications is their ability to adapt or to react according to the information of the patient’ context. In this talk, I will describe briefly three adaptation approaches, such as i) static (Aspect-oriented Programming), ii) Configuration (Spring), and iii) dynamic composition (OSGi) and parameters (MAPE). Then, I will illustrate dynamic approach to support adaptability of COPD diseases. In addition, I will give an overview and results of our context-aware healthcare systems.
Dr. Hamid Mcheick is a full professor in Computer Science department at the University of Québec at Chicoutimi, Canada. He has more than 20 years of experience in both academic and industrial area. He has done his PhD in Software Engineering and Distributed System in the University of Montreal, Canada. He is working on design and adaptation of distributed and smart software applications. He has supervised many post-doctorate, PhD, master and bachelor students. He has nine book chapters, more than 50 research papers in international journals and more than 130 research papers in international/national conference and workshop proceedings in his credit. Dr. Mcheick has given many keynote speeches and tutorials in his research area, particularly in Healthcare systems, Pervasive and Ubiquitous computing, Distributed Middleware Architectures, Software Connectors, Service Oriented Computing, Internet of Things (IoT), Mobile Edge Computing, Fog Computing, and Cloud Computing. Dr. Mcheick has gotten many grants from governments, industrials and academics. He is a chief in editor, chair, co-chair, reviewer, member in many organizations (such as IEEE, ACM, Springer, Elsevier, Inderscience) around the world.
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Extracellular Vesicles (EV) released by infective forms of Trypanosoma cruzi, the agent of Chagas’ disease, modulate inflammatory response of macrophages through the activation of Toll 2 receptor (TLR2) via mitogen-activated protein kinase pathway. This induces the production of nitric oxide (NO) and expression of the cytokines TNF-α, IL-12 and IL-6, which could explain the inflammation observed in experimental Chagas’ disease, and eventually in the progression of human disease. EVs released by the parasite are heterogeneous and it is unknown which factor, or factors present in the different vesicle populations act during the interaction with host cells. Objectives. The goal of the present work was to characterize and isolate the different populations of EVs released by T. cruzi and test their effects on macrophages. Methods. EV released by trypomastigotes forms of T. cruzi (Y strain) were purified by Asymmetric flow field-flow fractionation (AF4) and characterized by Nanoparticles tracking analysis (NTA). The different populations of EVs were incubated with host human monocytes cells (THP-1) and cytokines production determined by ELISA and qPCR. The different EV populations were also incubated with LLCMK-2 epithelial cells and the infection by T. cruzi determined. Results. We found two distinct populations of EVs. A population with 50 to 50 nm (EV1) and another with 100 to 120 nm (EV2). EV1 induced more TNF-alpha, IL-6, IP-10 and CCL20 than EV2. It was also more effective in promoting T. cruzi infection in epithelial cells. Conclusion. T. cruzi released two EV populations that affects differently host cells. Identification of these EVs composition might help to better understand the role of EVs in the modulation of T. cruzi infection.
Ana Claudia Torrecilhas Associate Professor from the Department of Biological Sciences, UNIFESP, is leading a lab focused on biology of Trypanosoma cruzi– the Chagas Disease parasite. My research concerns interaction parasite host interaction by secretion of extracellular vesicles and modulate host immune system. This is a new area of Chagas Disease research and only little is currently known about the precise mechanisms of parasite-derived extracellular vesicle cargo delivery and function. This research will lead to important advances in our fight against it as well as to the interesting findings at the field of cell–cell communication and pathogen–host interaction.
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